ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2019

9. Oncology and Chronic Disease

Fertility Issues in Chronic Diseases: New Insights

ey0016.9-8 | Fertility Issues in Chronic Diseases: New Insights | ESPEYB16

9.8. Long-term effects of childhood cancer treatment on hormonal and ultrasound markers of ovarian reserve

MH van den Berg , A Overbeek , CB Lambalk , GJL Kaspers , D Bresters , MM van den Heuvel-Eibrink , LC Kremer , JJ Loonen , HJ van der Pal , CM Ronckers , WJE Tissing , AB Versluys , M van der Heiden-van der Loo , AC Heijboer , M Hauptmann , JWR Twisk , JSE Laven , CCM Beerendonk , FE van Leeuwen , E van Dulmen-den Broeder , DCOG LATER-VEVO Study Group

Hum Reprod. 2018 Jul 6. [Epub ahead of print]. doi: 10.1093/humrep/dey229Childhood cancer treatment may compromise ovarian function in female childhood cancer survivors (CCSs), leading to delayed or arrested puberty, infertility, subfertility and adverse pregnancy outcomes. This Dutch nationwide retrospective cohort study collected measurements performed between 2008 and 2...

ey0016.9-9 | Fertility Issues in Chronic Diseases: New Insights | ESPEYB16

9.9. Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice

P Kadam , E Ntemou , Y Baert , S Van Laere , D Van Saen , E Goossens

To read the full abstract: Stem Cell Res Ther. 2018 Nov 21; 9 (1):317Spermatogonial stem cell transplantation (SSCT) could become a fertility restoration tool for childhood cancer survivors. However, the colonization efficiency of transplanted spermatogonial stem cells (SSCs) in animal models is about 12%, and the effectiveness of this procedure needs to be improved before clinical imple...

ey0016.9-10 | Fertility Issues in Chronic Diseases: New Insights | ESPEYB16

9.10. Cryopreservation of ovarian tissue may be considered in young girls with galactosemia

LS Mamsen , TW Kelsey , E Ernst , KT Macklon , AM Lund , CY Andersen

To read the full abstract: J Assist Reprod Genet. 2018 Jul; 35(7):1209.Galactosemia is an autosomal recessive genetic disorder of the galactose metabolism, caused by impaired activity of galactose-1-phosphate uridyltransferase (GALT). Complete deficiency or severely reduced activity of GALT affects approximately 1:30,000 to 1:50,000 persons. Girls and women with classic galactosemia have...

ey0016.9-11 | Fertility Issues in Chronic Diseases: New Insights | ESPEYB16

9.11. Ovarian reserve in young juvenile idiopathic arthritis patients

GRV Ferreira , RB Tomioka , NE Aikawa , EP Leon , GAR Maciel , PC Serafini , EC Baracat , C Goldenstein-Schainberg , RMR Pereira , E Bonfa , CA Silva

To read the full abstract: Mod Rheumatol. 2019 May; 29 (3):447In recent years, attention has been increasing on the ovarian reserve in juvenile rheumatic diseases (1–4). Premature ovarian failure is described in 3.5–7.5% of juvenile idiopathic arthritis (JIA) patients, mainly in older subjects (mean age 35 years) and in patients treated with chlorambucil for amyloidosis (5&#150...