ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2019

9. Oncology and Chronic Disease

Cancer Treatment and Growth Disorders

ey0016.9-12 | Cancer Treatment and Growth Disorders | ESPEYB16

9.12. Diagnosis of GH deficiency as a late effect of radiotherapy in survivors of childhood cancers

JG Sfeir , NEN Kittah , SU Tamhane , S Jasim , W Chemaitilly , LE Cohen , MH Murad

To read the full abstract: J Clin Endocrinol Metab. 2018 Aug 1; 103(8):2785GH deficiency (GHD) is common among children treated for cancer, especially among childhood cancer survivors (CCS) with tumors/surgery in the hypothalamic-pituitary (HP) region, CCS exposed to HP radiation or CCS exposed to cranial (CIR), craniospinal (CSI), or total body irradiation (TBI). However, most of existi...

ey0016.9-13 | Cancer Treatment and Growth Disorders | ESPEYB16

9.13. The predictive value of insulin-like growth factor 1 in irradiation-dependent growth hormone deficiency in childhood cancer survivors

A Cattoni , E Clarke , A Albanese

To read the full abstract: Horm Res Paediatr. 2018; 90(5): 314This single-centre, retrospective study analyzes the screening role of low IGF-1 levels in the diagnosis of growth hormone deficiency (GHD) in a cohort of 158 childhood cancer survivors (CCS) and in a selected sub-cohort of 117 CCS who received radiation for tumours not directly involving the hypothalamic-pituitary (HP) area (...

ey0016.9-14 | Cancer Treatment and Growth Disorders | ESPEYB16

9.14. GH therapy in childhood cancer survivors: a systematic review and meta-analysis

S Tamhane , JG Sfeir , NEN Kittah , S Jasim , W Chemaitilly , LE Cohen , MH Murad

To read the full abstract: J Clin Endocrinol Metab. 2018 Aug 1; 103(8): 2794This systematic review and meta-analysis was conducted by a US Endocrine Society Task Force in order to inform new guidelines on the management of childhood cancer survivors (CCS). The aim of this review was to evaluate the effects of GH therapy on final height, risk of diabetes mellitus, lipid abnormalities, met...