ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica
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Yearbook of Paediatric Endocrinology 2019

11 Obesity and Weight Regulation

Tracking, Programming, and Epigenetics

Previous section
New Insights into Body Weight Regulation
Table of contents
Next section
Metabolic Signaling

ey0016.11-5 | Tracking, Programming, and Epigenetics | ESPEYB16

11.5. Acceleration of BMI in early childhood and risk of sustained obesity

M Geserick , M Vogel , R Gausche , T Lipek , U Spielau , E Keller , R Pfaffle , W Kiess , A Korner

To read the full abstract: N Engl J Med. 2018;379(14):1303–1312.This analysis of longitudinal BMI data from early childhood to adolescents in 51,505 German subjects (CrescNet patient registry) allows a new insight into BMI development, specific dynamics and BMI trajectories from childhood to early adulthood.The exact pattern and time course of weight gain duri...
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ey0016.11-6 | Tracking, Programming, and Epigenetics | ESPEYB16

11.6. Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells

M Ejarque , V Ceperuelo-Mallafre , C Serena , E Maymo-Masip , X Duran , A Diaz-Ramos , M Millan-Scheiding , Y Nunez-Alvarez , C Nunez-Roa , P Gama , PM Garcia-Roves , MA Peinado , JM Gimble , A Zorzano , J Vendrell , S Fernandez-Veledo

To read the full abstract: Int J Obes (Lond). 2019;43(6):1256–1268This epigenome-wide association study in stromal/stem cells (ASCs), derived from subcutaneous adipose tissue samples of lean and obese subjects, revealed a specific DNA methylation signature in adipocyte precursors associated with obesity, which has a significant impact on the metabolic phenotype and the mitochondrial...
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ey0016.11-7 | Tracking, Programming, and Epigenetics | ESPEYB16

11.7. Transgenerational epigenetic mechanisms in adipose tissue development

S Lecoutre , P Petrus , M Ryden , C Breton

To read the full abstract: Trends Endocrinol Metab. 2018; 29(10):675–685This paper comprehensively reviews current knowledge on epigenetic mechanisms in adipose tissue that may account for transgenerational dysregulation of adipocyte formation and adipose tissue function.There is increasing evidence that adult-onset disorders, including obesity, may derive fro...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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