ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2020

4. Growth and Growth Factors

New perspectives

ey0017.4-7 | New perspectives | ESPEYB17

4.7. Circulating insulin-like growth factor-1 is positively associated with growth and cognition in 6- to 9-year-old schoolchildren from Ghana

B Grenov , A Larnkjaer , R Lee , A Serena , C Molgaard , KF Michaelsen , MJ Manary

To read the full abstract: J Nutr. 2020 Jun1;150(6):1405–1412.There is increasing evidence that dairy milk positively affects linear growth, weight and body composition in children, particularly in low- and middle-income countries (1)(2). This effect of milk on growth has been proposed to be mediated by IGF-I (2), (3). The aim of this double-blinded, controlled trial was to evaluate the effect of milk supplements on circulating IGF-I and to...

ey0017.4-8 | New perspectives | ESPEYB17

4.8. Deficits in bone geometry in growth hormone-deficient prepubertal boys revealed by high-resolution peripheral quantitative computed tomography

G. Baer Tamar , Agarwal Sanchita , Chen Shaoxuan , Chiuzan Codruta , Sopher Aviva B. , Tao Rachel , Hassoun Abeer , Shane Elizabeth , Fennoy Ilene , Oberfield Sharon E. , Vuguin Patricia M.

To read the full abstract: Horm Res Paediatr. 2019;92:293–301Growth hormone deficiency (GHD) in childhood may influence bone accrual and bone peak mass, ultimately affecting bone density in adulthood (1). In prepubertal GHD children, there is no evidence of increased risk of fractures, but relative lower bone density measured by dual X ray absorptiometry (DXA) has been reported. Interpretation of DXA values in small children is biased by bo...

ey0017.4-9 | New perspectives | ESPEYB17

4.9. Growth hormone deficiency and excess alter the gut microbiome in adult male mice

EA Jensen , JA Young , Z Jackson , J Busken , EO List , RK Carroll , JJ Kopchick , ER Murphy , DE Berryman

To read the full abstract: Endocrinology, April 2020, 161(4):1–18The aim of this study was to examine the role of growth hormone (GH) on gut microbiome and intestinal phenotype by using two animal models characterized by an opposite GH status: GH gene-disrupted (GH-/-) mice, characterized by GH deficiency; and bovine GH transgenic (bGH) mice with chronic GH excess. The abundance of common bacterial genera, such as Parasutterella, Ruminococc...

ey0017.4-10 | New perspectives | ESPEYB17

4.10. IGF-I in cord blood is predictive of final height in monozygotic twins with intratwin birth weight differences

C Kasner , S Schulte , F Schreiner , R Fimmers , B Stoffel-Wagner , P Bartmann , J Woelfle , B Gohlke

To read the full abstract: Clin Endocrinol (Oxf) 2020 May 13. doi: 10.1111/cen.14221. Online ahead of print.Children born either small for gestational age (SGA) or preterm usually do not achieve a final height (FH) in the mid-parental target height (MPTH) range, despite showing catch-up growth in the first years of life (1). The influence of intrauterine metabolic and hormonal factors has been p...

ey0017.4-11 | New perspectives | ESPEYB17

4.11. NPR2 Variants are frequent among children with familial short stature and respond well to growth hormone therapy

L Plachy , P Dusatkova , K Maratova , L Petruzelkova , D Zemkova , L Elblova , P Kucerova , L Toni , S Kolouskova , M Snajderova , Z Sumnik , J Lebl , S Pruhova

To read the full abstract: J Clin Endocrinol Metab. 2020 Mar 1;105(3):dgaa037.This study aimed to assess the frequency of natriuretic peptide receptor type B gene (NPR2 ) variants in 87 children with familial short stature (FSS) and evaluate their response to GH therapy. By applying whole-exome or custom-targeted NGS panel sequencing, NPR2 variants were found in 5 children (5.7%) belonging to 4 families. These variants were cla...