ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica
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Yearbook of Paediatric Endocrinology 2020

8. Adrenals

New Paradigms

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New Concerns
Table of contents
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Food for Thought

ey0017.8-16 | New Paradigms | ESPEYB17

8.16. GDF15 is elevated in conditions of glucocorticoid deficiency and is modulated by glucocorticoid replacement

A Melvin , D Chantzichristos , CJ Kyle , SD Mackenzie , BR Walker , G Johannsson , RH Stimson , S O’Rahilly

To read the full abstract: J Clin Endocrinol Metab. 2020; 105(5): 1427–1434. PMID: 31853550.GDF15 is a stress-induced hormone that acts in the hindbrain to activate neural circuits involved in aversive responses and reducing food intake and body weight in animal models (1). In humans, GDF15 is widely expressed, with highest concentrations seen in placental trophoblasts, followed by kid...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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