Endocr J. 2021 Apr 3. doi: 10.1507/endocrj.EJ21-0050. PMID: 33814485.
Mizue Fujii and colleagues retrospectively evaluated the pituitary function in 67 and 111 adult patients with Rathkes cleft cyst (RCC) and non-functioning pituitary adenoma (NFA), respectively. The study population represented consecutive patients encountered in their institute. They found that RCCs were smaller than NFAs and that anterior pituitary hormonal deficiencies were more frequent in the latter. A positive correlation was found between cyst/tumor size and a number of impaired hormones. However, some patients with even small RCCs exhibited pituitary dysfunction. Interestingly, compared with similar-sized NFAs, small RCCs tended to present more pituitary hormone deficiencies, which suggests that RCCs may impair hormone secretion more easily than NFAs. The authors speculate that this results from the location of RCCs between the anterior and posterior lobes, where they can potentially block anterior pituitary blood flow more effectively.