ISSN 1662-4009 (online)

ESPE Yearbook of Paediatric Endocrinology (2021) 18 1.5 | DOI: 10.1530/ey.18.1.5

ESPEYB18 1. Pituitary and Neuroendocrinology Development/Ontogeny (6 abstracts)

1.5. Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus

Zhou X , Zhong S , Peng H , Liu J , Ding W , Sun L , Ma Q , Liu Z , Chen R , Wu Q & Wang X

Nat Commun. 2020 Aug 13;11(1):4063. doi: 10.1038/s41467-020-17890-2. PMID: 32792525.

These researchers proposed the heterogeneity of hypothalamic neural progenitor cells. Other than traditional hypothalamic radial glial (hRG) cells, which are predominantly located in the ventricular zone, there are additional basal progenitors in the mantle zone, which are named as hypothalamic mantle zone radial glial (hmRG) cells. The researchers utilized lineage tracing to reveal the movement and division properties of hRG and hmRG cells. Meanwhile, they applied single cell RNA sequencing to investigate the diversity of hypothalamic neural progenitors, and found that HMGA2, a newly discovered neural progenitor marker, is involved in E2F1 pathway, regulating the proliferation of progenitor cells by targeting the downstream MYBL2.

This study provides the cellular and molecular features of different types of hypothalamic neural progenitors, which are essential for addressing the mechanism of hypothalamic neurogenesis.