ISSN 1662-4009 (online)

ESPE Yearbook of Paediatric Endocrinology (2021) 18 3 | DOI: 10.1530/ey.18.3

Paediatric Endocrinology and Diabetology, University Children’s Hospital Basel, and Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.


Over the last twelve months important clinical and basic research in the field of thyroidology was published. Here a rapid overview on important topics in the field: A better understanding of carcinogenesis through ionizing radiation came from a large genomic study on papillary thyroid cancer samples of patients exposed to radioactive iodine as children in 1986 in Chernobyl. A remarkable step in regeneration of thyroid function in thyroidectomized patients was achieved by patient-derived adult human thyroid cells cultured as organoids. The European Reference Network (ERN) initiated revision of the ESPE and EJE consensus guidelines on congenital hypothyroidism updated the current state of care of these patients throughout life. A randomized controlled trial comparing block and replace vs dose titration of anti-thyroid drugs in children with Graves’ disease showed no advantage of block and replace strategy on long-term stability. Further significant and innovative publications are summarized in the following chapter.

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