ISSN 1662-4009 (online)

Previous issue | Volume 19 | ESPEYB19 | Next issue

Yearbook of Paediatric Endocrinology 2022

10. Type 1 Diabetes

New treatments

ey0019.10-17 | New treatments | ESPEYB19

10.17. Efficacy of glucagon-like peptide-1 and estrogen dual agonist in pancreatic islets protection and preclinical models of insulin-deficient diabetes

T Fuselier , de Sa P Mota , MMF Qadir , B Xu , C Allard , MM Meyers , JP Tiano , BS Yang , V Gelfanov , SH Lindsey , RD Dimarchi , F Mauvais-Jarvis

Cell Rep Med 2022;3:100598. Summary: This study used a combination of mice models and cultured human islets to show that a glucagon-like peptide-1 (GLP-1) and estrogen (E2) dual agonist (GLP1-E2) provides superior protection from insulin-deficient diabetes compared to GLP-1 and E2 monoagonists. Pancreatic islet protection...