Adrenals

Svetlana Lajic; George Paltoglou; Leif Karlsson; Cetin Sirmen Kizilcan; Evangelia Charmandari

doi:10.1530/ey.22.8.0

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ESPE Yearbook of Paediatric Endocrinology (2025) 22 8.0 | DOI: 10.1530/ey.22.8.0

ESPEYB25 8. Adrenals Svetlana Lajic, George Paltoglou, Leif Karlsson, Sirmen Kizilcan Cetin, Evangelia Charmandari (1 abstracts)

8. Adrenals

Svetlana Lajic ¹ , George Paltoglou ^2* , Leif Karlsson ^1* , Sirmen Kizilcan Cetin ³ & Evangelia Charmandari ^2,4

Author affiliations

¹Department of Women´s and Children´s Health, Pediatric Endocrinology Unit Karolinska University Hospital/Karolinska Institutet, 171 76 Stockholm, Sweeden; ²Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital, Athens, 11527, Greece; ³Department of Pediatric Endocrinology, Ankara University Medical School, Ankara, 06230, Turkey; (YES member); ⁴Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, 11527, Greece.

*Equal author contribution

Introduction

For this year’s chapter on ‘Adrenals’, we searched PubMed for articles on ‘adrenal’ or ‘steroidogenesis’ published in English between June 1, 2024 and July 31, 2025. This yielded more than 7,000 citations. We have examined all citations individually and selected the following collection of clinical and basic research articles. Whenever possible, we have avoided topics that have been discussed in the Yearbook 2024, unless progress in the field has been incremental. Emerging themes for this year’s chapter include:i) SKA2 enhances stress-related glucocorticoid receptor signaling through FKBP4–FKBP5 interactions in neurons; ii) Cortisol awakening response prompts dynamic reconfiguration of brain networks in emotional and executive functioning; iii) Gut microbiota regulates stress responsivity via the circadian system; iv) International consensus statement on the diagnosis and management of pheochromocytoma and paraganglioma in children and adolescents; v) 17α-Hydroxylase/17,20-lyase Deficiency (17-OHD): A Meta-analysis of Reported Cases; vi) Prevalence of adrenal rest tumors and course of gonadal dysfunction in men with Congenital Adrenal Hyperplasia; and vii) Immunophenotypic implications of reverse-circadian glucocorticoid treatment in Congenital Adrenal Hyperplasia.