Oncology and Chronic Disease

Carla Bizzarri<SUP>1</SUP>; Sara Ciccone<SUP>1</SUP>; Stefania Pedicelli<SUP>1</SUP>; Cansu Koc<SUP>2</SUP>

doi:10.1530/ey.22.9.0

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ESPE Yearbook of Paediatric Endocrinology (2025) 22 9.0 | DOI: 10.1530/ey.22.9.0

ESPEYB25 9. Oncology and Chronic Disease Carla Bizzarri, Sara Ciccone, Stefania Pedicelli, Cansu Koc (1 abstracts)

9. Oncology and Chronic Disease

Carla Bizzarri ¹ , Sara Ciccone ¹ , Stefania Pedicelli ¹ & Cansu Koc ²

Author affiliations

¹Unit of Endocrinology and Diabetes, Bambino Gesù Childrens Hospital, IRCCS, Rome, Italy ²Department of Pediatric Endocrinology, Istanbul Faculty of Medicine, Istanbul University (YES member)

Recent data on childhood cancer survivors continue to highlight fertility preservation as a key focus area. Advances in fertility preservation methods and assisted reproduction have significantly improved reproductive outcomes compared to previous decades.

Additionally, the shift toward personalized antineoplastic therapies—tailored based on the patient’s genetic profile and tumor gene expression—has contributed to better preservation of fertility.

Emerging preliminary evidence also suggests a link between specific gene polymorphisms and the risk of endocrine complications, especially gonadal damage.