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8.2. Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion

A Berthon , N Settas , A Delaney , A Giannakou , A Demidowich , FR Faucz , SB Seminara , ME Chen , CA Stratakis

Hum Mol Genet. 2020 Dec 18;29(20): 34433450.https://pubmed.ncbi.nlm.nih.gov/33089319/The authors performed an experimental study in Kiss1 knock-out mice, followed by an observational study of patients with adrenal tumors. The findings indicate that KISS1/KISS1R signaling may be involved in obesity, metabolic disorders and even gonadal steroid hormone perturbations.<p class="abstex...

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ey0020.9-9 | Genetic Obesity and Genetic Risk Score | ESPEYB20

9.9. Genetic risk score enhances the risk prediction of severe obesity in adult survivors of childhood cancer

Y Sapkota , W Qiu , SB Dixon , CL Wilson , Z Wang , J Zhang , W Leisenring , EJ Chow , S Bhatia , GT Armstrong , LL Robison , MM Hudson , A Delaney , Y Yasui

Brief summary: This study evaluated the ability of genetic risk scores to predict severe obesity in adult survivors of childhood cancer. Data from 2548 survivors of European ancestry from the St. Jude Lifetime Cohort Study was analyzed and findings were validated in 6064 survivors from the Childhood Cancer Survivor Study. Survivors with higher genetic risk scores had significantly higher odds of severe obesity. Adding genetic risk scores to prediction models that included canc...

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ESPE Yearbook of Paediatric Endocrinology

8.2. Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion

9.9. Genetic risk score enhances the risk prediction of severe obesity in adult survivors of childhood cancer

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