ISSN 1662-4009 (online)

ey0018.8-11 | New Hope | ESPEYB18

8.11. New Horizons: Novel adrenal regenerative therapies

SR Bornstein , M Malyukov , C Heller , CG Ziegler , G Ruiz-Babot , A Schedl , B Ludwig , C Steenblock

J Clin Endocrinol Metab. 2020; 105(9): 3103–3107. this narrative review, the authors discuss the potential role of novel regenerative therapies for the treatment of adrenal insufficiency, including gene therapy and cell replacement strategies. More specifically, the authors discuss the heterogeneity in adrenal function in patients with Addison...

ey0015.10-21 | Prevention | ESPEYB15

10.21 Loss of intra-islet heparan sulfate is a highly sensitive marker of T1DM progression in humans

CJ Simeonovic , SK Popp , LM Starrs , DJ Brown , AF Ziolkowski , B Ludwig , SR Bornstein , JD Wilson , A Pugliese , TWH Kay , HE Thomas , T Loudovaris , FJ Choong , C Freeman , CR Parish

To read the full abstract: PLoS One. 2018;13:e0191360Up to now most studies to prevent autoimmune T1DM have focused on directly suppressing the autoimmune response rather than to better understanding the intrinsic requirements for beta cell survival. In this trial intracellular heparan sulfate was investigated as an essential requirement for the survival of beta cells and a marker for beta...