ESPE Yearbook of Paediatric Endocrinology

Brief summary: This randomized, controlled study in healthy-weight individuals examined the effect of a daily high-fat/high-sugar (HF/HS) intervention over 8 weeks on fat and sugar preference, alterations of brain response to food and sensory associative learning. It addressed the question, whether the association between obesity and altered brain function is pre-existing, is secondary to obesity or is attributed to western diet.Current models of obesity...

Nature. 2025 Mar;639(8055):708-716. doi: 10.1038/s41586-024-08504-8Brief Summary: This human cell and molecular atlas study used data from post-mortem tissue from 8 brain donors of normal body mass index (BMI). It combined single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptomics on 433,369 human hypothalamic cells to create a comprehensive transcriptional map of the hypothalam...