ISSN 1662-4009 (online)

ey0018.5-15 | Advances in skeletal biology | ESPEYB18

5.15. PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate

Nishimori Shigeki , Wein Marc N , Kronenberg Henry M

Bone. 2021 Jan;142:115709 Abstract: brief: In the developing bone, PTHrP signaling inhibits hypertrophic differentiation, the key step in the coupling of chondrogenesis and osteogenesis during endochondral bone formation. The current paper reviews findings of previous knockout-studies on PTHrP-induced signaling including HDAC4/5, salt-ind...

ey0018.5-16 | Advances in skeletal biology | ESPEYB18

5.16. Secondary ossification center induces and protects growth plate structure

Xie Meng , Herdina Anna Nele , Estefa Jordi , Medvedeva Ekaterina V , Li Lei , Newton Phillip T , Kotova Svetlana , Shavkuta Boris , Saxena Aditya , Shumate Lauren T , Metscher Brian D , Groszschmidt Karl , Nishimori Shigeki , Akovantseva Anastasia , Usanova Anna P , Kurenkova Anastasiia D , Kumar Anoop , Arregui Irene Linares , Tafforeau Paul , Fried Kaj , Carlstrom Mattias , Simon Andras , Gasser Christian , Kronenberg Henry M , Bastepe Murat , Cooper Kimberly L , Timashev Peter , Sanchez Sophie , Adameyko Igor , Eriksson Anders , Chagin Andrei S

Elife. 2020 Oct 16;9:e55212 Abstract: brief: In some species, growth plate and articular cartilage are not separated by secondary ossification centers. Here, the authors used mathematical modeling, ex vivo models and biophysical tests and indirectly demonstrate that secondary ossification centers evolved in order to protect the g...