ISSN 1662-4009 (online)

ey0018.5-15 | Advances in skeletal biology | ESPEYB18

5.15. PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate

Nishimori Shigeki , Wein Marc N , Kronenberg Henry M

Bone. 2021 Jan;142:115709 Abstract: brief: In the developing bone, PTHrP signaling inhibits hypertrophic differentiation, the key step in the coupling of chondrogenesis and osteogenesis during endochondral bone formation. The current paper reviews findings of previous knockout-studies on PTHrP-induced signaling including HDAC4/5, salt-ind...