ISSN 1662-4009 (online)

ey0018.1-1 | A Comprehensive Review of Hypopituitarism | ESPEYB18

1.1. Insights into non-classic and emerging causes of hypopituitarism

F Prodam , M Caputo , C Mele , P Marzullo , G Aimaretti

Nat Rev Endocrinol. 2021 Feb;17(2):114–129. doi: 10.1038/s41574-020-00437-2. PMID: 33247226.We highly recommend this comprehensive review by Prodam et al. to everyone as a starter to this chapter. How many of you knew that hypopituitarism in humans was first described just over 100 hundred years ago? The authors of this excellent review divide the causes of hypopituitarism...

ey0017.8-9 | New Genes | ESPEYB17

8.9. Primary adrenal insufficiency: New genetic causes and their long-term consequences

F Buonocore , JC Achermann

To read the full abstract: Clin Endocrinol (Oxf). 2020; 92(1): 11–20. PMID: 31610036.Primary adrenal insufficiency (PAI) is a relatively rare but potentially life?threatening condition that requires urgent diagnosis and treatment (1). Although the most common causes are congenital adrenal hyperplasia (CAH) in childhood and autoimmune adrenal insufficiency in adolescenc...

ey0016.3-14 | Graves’ Disease | ESPEYB16

3.14. Long-term methimazole therapy in juvenile Graves' disease: a randomized trial

F Azizi , M Takyar , E Madreseh , A Amouzegar

To read the full abstract: Pediatrics. 2019;143(5).This randomized prospective long-term study investigated the effect of long-term (8–10 years) versus short-term (18–24 months) methimazole therapy for Graves’ disease in 56 Iranian adolescents. The primary endpoint was disease remission at 48 months after stopping methimazole.The authors obs...

ey0015.4-5 | Important for clinical practice | ESPEYB15

4.5 Growth hormone improves cardiopulmonary capacity and body composition in children with growth hormone deficiency

D Capalbo , F Barbieri , N Improda , F Giallauria , E Di Pietro , A Rapacciuolo , R Di Mase , C Vigorito , M Salerno

To read the full abstract: J Clin Endocrinol Metab 2017; 102(11):4080-4088GH influences the structure and function of the heart. Untreated GHD adults have a worse cardiometabolic disease risk profile characterized by altered body composition, unfavorable changes in metabolism, reduced left ventricular mass and cardiac output and decreased exercise capacity [25-26]. GH...

ey0016.11-10 | Brown Adipose Tissue: The Story Goes On | ESPEYB16

11.10. Brown adipose tissue in prepubertal children: associations with sex, birthweight, and metabolic profile

R Malpique , JM Gallego-Escuredo , G Sebastiani , J Villarroya , A Lopez-Bermejo , F de Zegher , F Villarroya , L Ibanez

To read the full abstract: Int J Obes 2019; 43(2): 384–91Studies regarding brown adipose tissue (BAT) activity in children are scarce due to the difficulties in detecting BAT by imaging and the need for elaborate techniques to measure BAT activity. Here, prepubertal children born small for gestational age (SGA, n=41) and children born appropriate for gestational age (AGA, <...

ey0016.9-15 | Biologic Agents and Growth in Chronic Inflammatory Diseases | ESPEYB16

9.15. Growth during Tocilizumab therapy for Polyarticular-course juvenile idiopathic arthritis: 2-year data from a phase III clinical trial

KN Bharucha , HI Brunner , I Calvo Penades , I Nikishina , N Rubio-Perez , S Oliveira , K Kobusinska , H Schmeling , F Sztajnbok , F Weller-Heinemann , E Zholobova , F Zulian , R Allen , J Chaitow , J Frane , C Wells , N Ruperto , F De Benedetti

To read the full abstract: J Rheumatol. 2018; 45(8): 1173In recent years, biologic agents have clearly been shown to be effective in maintaining remission and improving linear growth in children with inflammatory bowel disease and other chronic inflammatory diseases (1–3). This prospective cohort study analyzed growth in 187 patients (143 females, mean age 11±4 years; including...

ey0017.4-10 | New perspectives | ESPEYB17

4.10. IGF-I in cord blood is predictive of final height in monozygotic twins with intratwin birth weight differences

C Kasner , S Schulte , F Schreiner , R Fimmers , B Stoffel-Wagner , P Bartmann , J Woelfle , B Gohlke

To read the full abstract: Clin Endocrinol (Oxf) 2020 May 13. doi: 10.1111/cen.14221. Online ahead of print.Children born either small for gestational age (SGA) or preterm usually do not achieve a final height (FH) in the mid-parental target height (MPTH) range, despite showing catch-up growth in the first years of life (1). The influence of intrauterine metabolic and hormonal factors has been p...

ey0018.5-3 | Advances in clinical practice | ESPEYB18

5.3. Mutation of SGK3, a novel regulator of renal phosphate transport, causes autosomal dominant hypophosphatemic Rickets

Cebeci Ayşe Nurcan , Zou Minjing , BinEssa Huda A , Alzahrani Ali S , l-Rijjal Roua A , Al-Enezi Anwar F , Al-Mohanna Futwan A , Cavalier Etienne , Meyer Brian F , Shi Yufei

J Clin Endocrinol Metab. 2020 Jun 1;105(6):dgz260. Abstract: https://pubmed.ncbi.nlm.nih.gov/31821448/In brief: In large kindred including five hypophosphatemic rickets (HR) patients with a pattern of autosomal dominant inheritance, a novel c.979–96 T>A variant in the SGK3 gene segregated perfectly with the phenotype, i.e. present in all 5 patients and in none of ...

ey0016.5-2 | New Therapies and Novel Therapeutic Strategies | ESPEYB16

5.2. Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment

F Zaman , Y Zhao , B Celvin , HH Mehta , J Wan , D Chrysis , C Ohlsson , B Fadeel , P Cohen , L Savendahl

Abstract: FASEB J. 2019;33:4962–4974.In brief: Glucocorticoid-induced growth impairment is reverted by the mitochondrial peptide humanin in dexamethasone-treated mice without attenuation of anti-inflammatory effects.Comment: Humanin (HN) is a 24 aminoacid peptide that was originally discovered as a neuroprotective factor and later shown ...

ey0017.7-12 | Basic Science | ESPEYB17

7.12. Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3

V Heras , S Sangiao-Alvarellos , M Manfredi-Lozano , MJ Sanchez-Tapia , F Ruiz- Pino , J Roa , M Lara-Chica , R Morrugares-Carmona , N Jouy , AP Abreu , V Prevot , D Belsham , MJ Vazquez , MA Calzado , L Pinilla , F Gaytan , AC Latronico , UB Kaiser , JM Castellano , M Tena-Sempere

To read the full abstract: PLoS biology vol. 17,11 e3000532. 7 Nov. 2019. doi: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000532This study unravels the role of the miR-30/Mkrn3 pathway in the hypothalamic regulation of puberty Puberty onset is triggered by a hypothalamic network of interconnected...