ISSN 1662-4009 (online)

ey0018.1-1 | A Comprehensive Review of Hypopituitarism | ESPEYB18

1.1. Insights into non-classic and emerging causes of hypopituitarism

F Prodam , M Caputo , C Mele , P Marzullo , G Aimaretti

Nat Rev Endocrinol. 2021 Feb;17(2):114–129. doi: 10.1038/s41574-020-00437-2. PMID: 33247226.We highly recommend this comprehensive review by Prodam et al. to everyone as a starter to this chapter. How many of you knew that hypopituitarism in humans was first described just over 100 hundred years ago? The authors of this excellent review divide the causes of hypopituitarism...

ey0015.11-3 | New insight into obesity comorbidities | ESPEYB15

11.3 Body mass index and kidney disease-related mortality in midlife: A nationwide cohort of 2.3 million adolescents

G Twig , A Vivante , T Bader , E Derazne , AM Tsur , M Levi , N Goldberger , A Leiba , JD Kark

To read the full abstract: Obesity 2018;26(4):776-781Here, Twig et al. shed light on an important, but not well investigated facet of the complex, multi-organ system chronic disease simply termed ‘obesity’. Using the large statistical power of this impressive, nation-wide database, the authors demonstrate high hazard ratios for obesity-related kidney mortality in a relatively young cohort...

ey0015.8-10 | Important for Clinical Practice | ESPEYB15

8.10 Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017

D Annane , SM Pastores , B Rochwerg , W Arlt , RA Balk , A Beishuizen , J Briegel , J Carcillo , M Christ-Crain , MS Cooper , PE Marik , G Umberto Meduri , KM Olsen , SC Rodgers , JA Russell , G Van den Berghe

To read the full abstract: Crit Care Med. 2017; 45(12): 2078-2088This guideline replaces/updates the 2008 recommendations regarding the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in adult and pediatric patients. In CIRCI, inadequate glucocorticoid-mediated anti-inflammatory activity is observed in relation to the severity of the critical illne...

ey0016.15-7 | (1) | ESPEYB16

15.7. Association of early introduction of solids with infant sleep: A secondary analysis of a randomized clinical trial

MR Perkin , HT Bahnson , K Logan , T Marrs , S Radulovic , J Craven , C Flohr , G Lack

To read the full abstract: JAMA Pediatr 2018;172:e180739.This randomised controlled trial of 1303 exclusively breastfed 3-month-old UK infants was primarily performed to test the impact of early introduction of solid foods, from age 3 months, on the risk of food allergies (1). Sleep was measured as a secondary trial outcome: the trial showed that early introduction of solids increa...

ey0016.3-4 | Thyroid Hormone Action | ESPEYB16

3.4. Non-thyroidal illness syndrome in critically ill children: prognostic value and impact of nutritional management

A Jacobs , I Derese , Perre S Vander , Puffelen E van , S Verstraete , L Pauwels , S Verbruggen , P Wouters , L Langouche , Guerra G Garcia , K Joosten , I Vanhorebeek , Berghe G Van den

To read the full abstract: Thyroid. 2019;29:480–492.The thyroid axis is particularly responsive to critical illness. Adaptation processes of the thyroid axis to critical illness and prolonged fasting are well described as non-thyroidal illness syndrome. Non-thyroidal illness is mainly explained by two mechanisms: 1) peripheral inactivation of T4 to rT3 by decreased type-1 deiodinase...

ey0015.8-9 | Important for Clinical Practice | ESPEYB15

8.9 The short cosyntropin test revisited - new normal reference range using LCMSMS

GÅ Ueland , P Methlie , M Øksnes , HB Thordarson , J Sagen , R Kellmann , G Mellgren , M Ræder , P Dahlqvist , SR Dahl , PM Thorsby , K Løvås , ES Husebye

To read the full abstract: J Clin Endocrinol Metab. 2018; 103(4):1696-1703How we measure steroids has been a constant debate in recent years because current routinely used immunoassays lack both specificity and sensitivity. Therefore, chromatographic, mass spectrometric methods have been pushed forward for their higher sensitivity and specificity, and for their advantage to provide multiple measu...

ey0015.3-10 | Graves’ disease | ESPEYB15

3.10 Long-term outcome of thyrotoxicosis in childhood and adolescence in the west of Scotland: the case for long-term antithyroid treatment and the importance of initial counselling

M Kourime , S McGowan , M Al Towati , SF Ahmed , G Stewart , S Williamson , I Hunter , MDC Donaldson

To read the full abstract: Arch Dis Child 2018;103:637-642Management of thyrotoxicosis in children and adolescents remains challenging and treatment varies considerably among institutions. The patient’s age, clinical status and likelihood of remission should be considered when counseling patients and parents. Nevertheless, individual prognosis of antithyroid drug treated Graves’ diseas...

ey0017.9-17 | Cancer Treatment, Growth and Growth Hormone | ESPEYB17

9.17. Final height in growth hormone-deficient childhood cancer survivors after growth hormone therapy

G Rodari , A Cattoni , A Albanese

To read the full abstract: J Endocrinol Invest. 2020 Feb;43(2):209–217. giulia.rodari@unimi.itGrowth hormone deficiency (GHD) is the most common endocrine late effect in children with tumours involving the hypothalamus-pituitary (HP) area or exposed to cranial, craniospinal or total body radiotherapy (RT). The location of brain tumours in continuity with the sellar/suprasellar area and HP radiatio...

ey0015.3 | (1) | ESPEYB15

3. Thyroid

A Stoupa , G Szinnai

A selection of papers with high impact challenging current knowledge and practice in pediatric thyroidology were published during the last year. On the molecular level, the proof of intracellular compartmentalization of the TSH/TSHR signaling cascade changes our view on TSH/TSHR signaling adding an new level of regulation. On the hormonal level, the fact that thyroid hormones regulate cardiac function and metabolic activity mainly by a noncanonical thyroid hormone receptor ind...

ey0015.5-13 | Live insights to growth plate biology | ESPEYB15

5.13 Imaging IGF-I uptake in growth plate cartilage using in vivo multiphoton microscopy

MA Serrat , G Ion

To read the full abstract: J Appl Physiol (1985) 2017;123:1101-1109IGF-1 is a major regulator of growth plate chondrocyte proliferation. While knockout studies reveal substantial impact from both systemic as well from locally-derived IGF-1, transport and distribution patterns within the growth plate remain unknown. Theoretical approaches have been developed to understand the distributio...