ESPEYB15 5 Bone, Growth Plate and Mineral Metabolism Growth velocity as a laboratory parameter (1 abstracts)
5.10 A degradation fragment of type X collagen is a real-time marker for bone growth velocity
Coghlan RF , Oberdorf JA , Sienko S , Aiona MD , Boston BA , Connelly KJ , Bahney C , LaRouche J , Almubarak SM , Coleman DT , Girkontaite I , von der Mark K , Lunstrum GP & Horton WA
Research Center, Shriners Hospitals for Children, and Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA
To read the full abstract: Sci Transl Med 2017;9(419)
Can growth velocity be monitored by a lab test? Previous approaches to this methodological challenge focused on the correlation of linear growth to more established parameters such as C-type natriuretic peptide (CNP). Potentially more specific markers of endochondral ossification - with the exception of amino-terminal propeptide of CNP (NTproCNP) - have drawn little attention so far. Here, Coghlan et al. identified Collagen X fragments (CXM) as an entirely novel parameter and were able to employ a specific ELISA for clinical testing. As high amounts of type X collagen are synthesized by hypertrophic chondrocytes, chondroclastic activity and extra-cellular matrix degradation liberate fragments of this highly specific growth plate matrix compound.
Validation was performed in a population of 83 healthy children revealed an impressively high correlation with growth velocity (r2=0.88), although the relatively small sample set especially for higher velocity values has to be taken in account. In addition, CXM has to match with other parameters such as NTproCNP, for which age and Tanner-specific data already have been established (1). While further studies will clarify the advantages of individual competing parameters, Coghlan et al. have taken the perspective of clinical “live growth monitoring” another step forward.
1. Olney RC, Permuy JW, Prickett TC, Han JC, Espiner EA. Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) predicts height velocity in healthy children. Clin Endocrinol (Oxf). 2012;77(3):416-422.
Volume 15
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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