ESPEYB16 8. Adrenals New Mechanisms (3 abstracts)
8.2. Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress
Steenblock C , Rubin de Celis MF , Delgadillo Silva LF , Pawolski V , Brennand A , Werdermann M , Berger I , Santambrogio A , Peitzsch M , Andoniadou CL , Schally AV & Bornstein SR
Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany
To read the full abstract: Proc Natl Acad Sci USA. 2018; 115(51): 12997–13002.
Humans are constantly challenged by multiple stressors, to which the body’s response and adaptation are essential. The adrenal gland plays a major role in the response to both physiological challenges and stress. Maintenance of the adrenal is partly accomplished by proliferation and differentiation of adult progenitors and stem cells in the adrenal cortex and medulla. In previous studies, the authors demonstrated a direct effect of adrenocortical growth factors and androgens on proliferation and differentiation of adult adrenomedullary chromaffin cells (7) and chromaffin progenitor cells (8). They also showed that Nestin+ stem-like cells in the adrenal medulla play an important role under stress, predominantly differentiating into chromaffin cells (9).
In the present study, they characterized a distinct population of Nestin+ progenitors in the murine adrenal cortex and analyzed its role in stress. Under basal conditions, these progenitors very slowly migrate centripetally through the different zones of the adrenal cortex to the cortical–medullary boundary. However, under stress, the progenitors migrate faster and differentiate into steroidogenic cells. In addition, they isolated the Nestin+ cells from the adrenal cortex, characterized them in vitro and showed that they display progenitor characteristics and are able to generate functional cells producing steroid hormones. These findings demonstrate the coordinated action of stress-inducible stem cells to ensure tissue remodeling and cellular and functional adaptation to stress.
References: 7. Sicard F, et al. Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (DHEA), and DHEA sulfate. Proc Natl Acad Sci USA 2007; 104:2007–2012.
8. Chung KF, Qin N, Androutsellis-Theotokis A, Bornstein SR, Ehrhart-Bornstein M. Effects of dehydroepiandrosterone on proliferation and differentiation of chromaffin progenitor cells. Mol Cell Endocrinol 2011; 336:141–148.
9. Rubin de Celis MF, et al. Multipotent glia-like stem cells mediate stress adaptation. Stem Cells 2015; 33:2037–2051.
Volume 16
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more