ESPEYB19 11. Obesity and Weight Regulation Weight regulation and endocrine circuits (including interventions) (7 abstracts)
11.16. Exenatide for weight-loss maintenance in adolescents with severe obesity: A randomized, placebo-controlled trial
Fox CK , Clark JM , Rudser KD , Ryder JR , Gross AC , Nathan BM , Sunni M , Dengel DR , Billington CJ , Bensignor MO & Kelly AS
Center for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Lusc0001@umn.edu Obesity (Silver Spring) 2022, 30(5):1105–1115. https://doi.org/10.1002/oby.23395
Brief Summary: This 52-week randomised placebo-controlled trial showed that exenatide XR improves stabilisation of BMI reduction after lifestyle intervention in adolescents with obesity.
Maintaining weight loss after an intensive lifestyle intervention is usually unsuccessful, especially in adolescents with obesity. In addition to genetic factors with variable effects, factors of living conditions and individual self-control, there is also a physiological increase in the natural course of BMI values in adolescence. Studies investigating the maintenance of BMI reduction after intervention are of particular importance.
The use of incretin mimetica, in this case the long-lasting GLP-1 receptor agonist exenatide XR, is currently an innovative and effective approach in the pharmacological therapy of obesity. Although there was a clear effect of pharmacological treatment, it did not reach statistical significance. In future, larger numbers of cases should be included in studies. It is possible that more potent incretin mimetica will deliver better results.
The variability of the BMI trajectories after initial weight loss was very high. We do not yet understand the reason for this. The high heterogeneity in the course of BMI shows that it is useful to identify prognostic factors for the therapeutic response in future studies. These might primarily be genetic factors.
To our knowledge, this is the first RCT to specifically target pharmacological interventions for weight maintenance after weight loss in obese adolescents. Special mention should also be made of the fact that there were only mild side effects which were comparable in the intervention and control groups.
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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