ESPEYB20 1. Thyroid Pediatric Thyroid Cancer (2 abstracts)
1.13. 2022 European Thyroid Association Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma
Lebbink CA , Links TP , Czarniecka A , Dias RP , Elisei R , Izatt L , Krude H , Lorenz K , Luster M , Newbold K , Piccardo A , Sobrinho-Simões M , Takano T , Paul van Trotsenburg AS , Verburg FA & van Santen HM
Eur Thyroid J. 2022 Nov 29;11(6):e220146. doi: 10.1530/ETJ-22-0146. Print 2022 Dec 1. PMID: 36228315
Brief summary: American Thyroid Association Guidelines for management of children with thyroid nodules and differentiated thyroid cancer were published in 2015 (1). Now Lebbink et al. published management guidelines from the European Thyroid Association.
Pediatric differentiated thyroid carcinoma is rare. For many aspects of the disease (diagnosis, treatment, follow-up) clear evidence from randomized controlled trials are therefore missing. The presented management guidelines reviewed the current literature and present 29 recommendations ranging from organization of care of a multidisciplinary thyroid team, diagnostic evaluation of thyroid nodules, detailed recommendation for surgical management of differentiated thyroid carcinoma, indication for I-131 therapy, molecular testing, and targeted therapy, follow-up, and late effects of treatment.
Especially the new, but only in case reports described options of targeted therapies in patients with refractory disease should clearly only be performed in clinical studies (2).
In summary, this paper represents an extensive review and interpretation of the actual knowledge on pediatric thyroid nodules and pediatric differentiated carcinoma. Together with the 2015 published ATA Guidelines it provides important guidance for optimal treatment of affected patients.
References: 1. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force. Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid. 2015 Jul;25(7):716–759. doi: 10.1089/thy.2014.0460. PMID: 25900731. 2. NTRK and RET fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake. Lee YA, Lee H, Im SW, Song YS, Oh DY, Kang HJ, Won JK, Jung KC, Kwon D, Chung EJ, Hah JH, Paeng JC, Kim JH, Choi J, Kim OH, Oh JM, Ahn BC, Wirth LJ, Shin CH, Kim JI, Park YJ. NTRK and RET fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake. J Clin Invest. 2021 Sep 15;131(18):e144847. doi: 10.1172/JCI144847. PMID: 34237031.
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ESPE Yearbook of Paediatric Endocrinology
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