ISSN 1662-4009 (online)

ey0020.9-13 | Obesity and Insulin/Glucose Metabolism | ESPEYB20

9.13. Lack of evidence for a causal role of hyperinsulinemia in the progression of obesity in children and adolescents: a longitudinal study

R Halloun , A Galderisi , S Caprio , R Weiss

Brief summary: This longitudinal study aimed to determine if hyperinsulinemia and postprandial glucose levels could predict obesity progression in n=591 children and adolescents with obesity. The authors found no association between hyperinsulinemia, insulin secretion, low postprandial glucose levels, and an increase in obesity over a 2–4-year period.According to the carbohydrate-insulin model (1), diets with a high glycemic load (GL) promote weight...

ey0020.11-6 | Diabetes | ESPEYB20

11.6. Treatment of diabetic ketoacidosis with subcutaneous regular insulin in a non-ICU setting is effective and economical: A single-center experience

A Ayyavoo , A Ravikulan , R Palany

Brief summary: Since 2014, children with DKA have been managed on the general ward (instead of the intensive care unit [ICU]) and with SC insulin (instead of IV insulin) at G Kuppuswamy Naidu Memorial Hospital in Coimbatore, India. This retrospective study compares the cost and outcomes of IV (2013–2014) and SC insulin treatment (2017).In high-income countries (HICs), DKA management commonly includes IV insulin. The 2022 ISPAD Clinical Practice Cons...

ey0018.2-21 | Fetal and Neonatal Cortisol and Growth Hormone Physiology | ESPEYB18

2.21. Evaluating the low-dose ACTH stimulation test in neonates: ideal times for cortisol measurement.

R LeDrew , E Bariciak , R Webster , N Barrowman , A Ahmet

J Clin Endocrinol Metab. 2020 Dec 1;105(12):dgaa635. doi: 10.1210/clinem/dgaa635. PMID: 32901267.The authors performed a retrospective analysis of low dose synacthen tests performed in 49 neonates from January 1, 2009 to September 30, 2017 in a tertiary-care pediatric center. Of samples measured at 15, 30, and 60 minutes, the majority of neonates showed a peak cortisol level at 60 minutes.<...

ey0019.6-8 | Basic and Genetic Research of DSD | ESPEYB19

6.8. Targeting the non-coding genome for the diagnosis of disorders of sex development

G Atlas , R Sreenivasan , A Sinclair

Sex Dev. 2021;15(5-6):392-410. PMID: 34634785, doi: 10.1159/000519238. Brief Summary: This review summarizes how non-coding genomic variants are identified and validated, and why non-coding defects found in DSD patients have to be considered when investigating the genetic etiology of DSD.Accurate genetic diagnosis of 46,XY DSD patients remains crucial for early treatment and ...

ey0016.6-17 | New Working Hypotheses in Transgender | ESPEYB16

6.17. Gender identities in adolescent population: methodological issues and prevalence across age groups

R Kaltiala-Heino , N Lindberg

Eur Psychiatry. 2019 Jan;55:61–66.doi: 10.1016/j.eurpsy.2018.09.003. PubMed ID: 30390473Is the prevalence of gender dysphoria today truly increasing, or do the increasing numbers result because today’s world is more open so that these individuals and families no longer hide in the closet? Or are methodological factors playing a role? Fact is that in Eu...

ey0018.7-8 | Basic Science | ESPEYB18

7.8. Oral contraceptive use, especially during puberty, alters resting state functional connectivity

R Sharma , Z Fang , A Smith , N Ismail

Horm Behav. 2020;126:104849. 10.1016/j.yhbeh.2020.104849. https://www.sciencedirect.com/science/article/abs/pii/S0018506X20301756?via%3DihubIn brief: This study used functional MRI to compare resting state functional connectivity in women who started oral contraception during puberty or ad...

ey0017.12-16 | Hyperlipidemia | ESPEYB17

12.16. Identification of ALK in thinness

M Orthofer , A Valsesia , R, et al. Magi

To read the full abstract: Cell. 2020. doi: 10.1016/j.cell.2020.04.034Short summary: In this study, rather than focusing on genes associated with obesity, the authors studied genetic variants associated with thinness (BMI <6th percentile for age). In a genome-wide association study from the Estonian Biobank, 881 people were classified as thin, and 3173 individuals with norm...

ey0020.4-5 | Novel Players in the Pathogenesis of DSD | ESPEYB20

4.5. CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice

N Okashita , R Maeda , M Tachibana

Brief summary: This in vivo study identifies a new gene, CDYL (Chromodomain Y-like protein) in the epigenetic control of sex determination in mice.Recent findings on mammalian sex development suggest that the fate decision of bipotential gonads depends not only on transcriptional activation of Y-linked testis-determining gene (SRY/Sry) but also on a delicate expression balance between the mutually antagonistic pro-testis and pro-ovarian genes. P...

ey0018.15-10 | (1) | ESPEYB18

15.10. Maternal occupational exposure to endocrine-disrupting chemicals during pregnancy and semen parameters in adulthood: results of a nationwide cross-sectional study among Swiss conscripts

Istvan M , Rahban R , Dananche B , Senn A , Stettler E , Multigner L , Nef S , Garlantezec R

Human Reproduction, 2021; 36(7): 1948–1958https://bit.ly/3vtcByFThis cross-sectional study shows that men who had been exposed in utero to endocrine disruptors (EDC) are twice more likely to have a low sperm count, below the reference values per ejaculation set by the World Health Organisation.Male reproductive function is known to be highly sensitive to a number of chemical compou...

ey0019.13-17 | Endocrinology | ESPEYB19

13.17. Health-related quality of life and fatigue perception in children with congenital adrenal hyperplasia: a developing nation perspective

R Daniel , J Yadav , R Kumar , P Malhi , A Sharma , D Dayal

jai1984yadav@gmail.com Pediatr Endocrinol Diabetes Metab 2021; 27: 266–271. doi: 10.5114/pedm.2021.109269Brief Summary: The questionnaire-based case control study found that children with classical congenital adrenal hyperplasia (CAH) in northern India reported lower quality of life (QOL), poorer sleep and increased fatigue compared to healthy...