ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Stroke 2018;49:579-585Height is regulated by interplay of several factors, including genetic background, intra- and extra-uterine environment, nutrition, and others. Adult height has been inversely related with stroke risk [34] and coronary artery disease [35]...

To read the full abstract: PLoS Biol 2018;16:e2004399The hypothalamus plays a central role in the control of numerous physiological pathways and received afferent pathways from the brain and from the periphery. For instance, body temperature changes in peripheral tissues are conveyed to the hypothalamus via the bloodstream. An increase of temperature within the hypothalamus results in an i...

To read the full abstract: Cochrane Database Syst Rev. 2017; 11:CD008727Glucocorticoids (GCs), such as prednisone (prednisolone) or dexamethasone, are essential agents in the treatment of acute lymphoblastic leukemia (ALL), the most common malignancy in childhood. They are administered in highly supraphysiologic doses in cyclic courses. Thus, every pediatric endocrinologist fears HPA axi...

To read the full abstract: Diabetes Care. 2018;41:303-310One of the major short term complications of T1DM is the imminent risk of hypoglycemia during insulin treatment. In addition and importantly, long term complications of diabetes include those induced by frequent hypoglycemia, namely neurologic and developmental impairment upon frequent hypoglycemic episodes at a young age. In addition, it is de...

To read the full abstract: N Engl J Med. 2020;382:341–352.Teprotumumab, an IGF-1R monoclonal antibody, showed promising results for the treatment of Graves’ orbitopathy in a first phase 2 study reported in 2017 [1]. Here, this randomized double-masked, placebo controlled phase 3 multicenter study confirms those initial promising results in patients with moderate-to severe Graves’ eye disease: The primary outcome of proptosis reduc...

In Brief: The authors describe a wide range of studies. Firstly, observational studies showed that circulating taurine concentrations decline with age in mice, monkeys, and humans – and in the latter, low taurine was associated with metabolic disease (abdominal fat, blood pressure, Type 2 diabetes). They then gave oral taurine to mice throughout their lives and showed that this increased lifespan by 10–12% and improved functional outcomes of almost all tissues studie...