ESPEYB15 1 Pituitary and Neuroendocrinology New mechanisms (6 abstracts)
1.2 Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake
Jeong JH , Lee DK , Liu SM Chua SC , Jr. , Schwartz GJ & Jo YH
Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, New York, USA
To read the full abstract: PLoS Biol 2018;16:e2004399
The hypothalamus plays a central role in the control of numerous physiological pathways and received afferent pathways from the brain and from the periphery. For instance, body temperature changes in peripheral tissues are conveyed to the hypothalamus via the bloodstream. An increase of temperature within the hypothalamus results in an increase of hypothalamic neuron activity. TRPV receptors have been proposed to translate the rise of temperature in a neuronal signal and to a physiological response. The originality of this study is based on the hypothesis that hypothalamic neurons responding to an acute change of temperature should be located outside the blood-brain barrier (BBB). POMC neurons are anorexigenic. Some of POMC neurons in the arcuate nucleus (ARC) are located outside the BBB. It was therefore tempting to test the hypothesis that activation of ARC POMC neurons by changes in temperature could reduce food intake. These results link acute elevation in peripheral and brain temperature with acute reductions in food-intake via activation of TRPV-like receptors. This study provides additional evidence of the central role of the hypothalamus in the control of the homeostasis of numerous physiological pathways in addition to endocrine axes.
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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