ESPE Yearbook of Paediatric Endocrinology

Brief summary: The WHO List of Essential Medicines now includes more than 400 medicines. The addition to the list of medicines considered effective, safe, and important for priority public health is made increasingly complicated by the high cost of new drugs. This commentary recommends a new approach whereby consideration would be given separately to economic aspects and to clinical benefits.Every two years, the WHO publishes a revised List of Essential ...

To read the full abstract: Pharm Res. 2018 Dec 5;36(1):21.Smectite purified from bentonite clay, and laponite SD-LAP, a synthetic Smectite were fed to rodents on a high-fat diet. Over a two-week period both the engineered clay and orlistat had weight loss effects.The unanticipated discovery that clay has a unique ability to “soak up” fat droplets in the g...

Brief summary: This review article draws on existing studies of type 1 diabetes (T1D) in sub-Saharan Africa, examining differences in phenotype, genetic susceptibility and rates of autoimmunity within this population. Lack of large prospective studies with well-standardized methodologies are noted in this population, making more definitive studies necessary.This article reviews studies reporting the clinical features of patients with T1D in sub-Saharan A...

jcmbanya@yahoo.co.uk Pediatr Diabetes 2022; 23: 33–37. doi: 10.1111/pedi.13294Brief Summary: Despite provision of free insulin by the Changing Diabetes in Children (CDiC) program, mortality remains high in children and adolescents with type 1 diabetes (T1D) in Cameroon, in particular in rural settings and in families with no formal education.<p cl...

To read the full abstract: Am J Clin Nutr. 2019 Apr 4The study analyzed relationships between maternal obesity and human milk metabolites, infant body composition, and postnatal weight gain.Maternal obesity is one of the strongest predictors of childhood obesity. Although the mechanism/s by which this obesity risk is transmitted to the offspring are not known diffe...

Pediatr Diabetes. 2019;20:93–98. DOI: 10.1111/pedi.12801• The quality and availability of pediatric diabetes management varies from setting to setting depending on the available resources.• In this position paper, the authors propose a ‘levels of care’ concept with three tiers that stratifies the existing levels of care into minimal care, interm...

To read the full abstract: Hum Mol Genet. 2017; 26(18): 3600-3614X-linked adrenoleukodystrophy (ALD) is caused by genetic mutations in the ABCD1 gene coding for a peroxisomal transmembrane protein responsible for the metabolism of very long chain fatty acids (VLCFA). It manifests with a broad phenotype mainly involving the peripheral and central nervous system and the adrenals. However, the exact pa...

ISPAD Jenious Group. Pediatr Diabetes. 2021;22:1115-1119. https://pubmed.ncbi.nlm.nih.gov/34741569/Brief Summary: This cross-sectional survey describes healthcare professionals’ (HCPs) experiences of telemedicine use in diabetes centers across the world, along with the adaptations and challenges associated with its implementation.This is one out of several public...

To read the full abstract: Proc Natl Acad Sci USA 2018; 115(17) E3914-E3921Pediatric endocrinologists have long known that chronic disease, such as severe asthma or inflammatory bowel disease, leads to slower growth and short stature. But it is not always clear whether this is due to the disease (decreased oxygen to the tissues, decreased absorption of calories, infections), to the treatment (c...

To read the full abstract: BMJ Open Diabetes Research and Care2019; 7:e000721. PMID: 31908791Understanding of the molecular mechanisms underlying neonatal diabetes mellitus (NDM) has helped to transform the clinical management of some patients. Those with NDM due to mutations in the KCNJ11/ABCC8 genes can now be switched to oral sulphonylurea treatment and their daily insu...