ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Clinical Orthopaedics and Related Research. 476(11):2112–2122, 2018The century-long Fels Longitudinal Study of human growth and development aimed to track when growth plate fusion started and completed in children born as far back as 1915. Among 1292 children, each with between 1 to 30 serial left hand-wrist radiographs, children born in the 1990s reached ...

To read the full abstract: Endocrinology. 2018 Jul 1;159(7):2676–2682.The authors compared the effects of leptin versus weight loading using intraperitoneal weighted capsules (‘gravitostat stimulation’) on changes in fat mass in mice. Leptin infusion suppressed body weight and fat mass in lean but not in overweight or obese mice. Weight loading decreased body weight in ove...

To read the full abstract: Nature 2017;548:52-57The central nervous system contributes to ageing. The hypothalamus seems to be particularly important in this process. Recent studies have demonstrated a link between ageing and a decrease of neurogenesis in the hippocampus and the subventricular zone of the lateral ventricle in the brain. Neural stem/progenitor cells (NSC) reside in those regions in ...

To read the full abstract: Endocr Rev 2018;39:3,333This review is interesting for several reasons. It focuses on a specific type of cells lining the wall of the third ventricle in the median eminence of the hypothalamus. This region acts both as a secretor of neuropeptides and as a sensor of the metabolic status of the periphery. These two functions imply a bidirectional physiological pathway: br...

To read the full abstract: Proc Natl Acad Sci U S A 2017;114:E11323-E11332The mechanism of thyroid hormone (TH) action is classically attributed to thyroid hormone receptor (THR) binding to thyroid hormone responsive elements (TRE) in promotors of target genes, directly controlling gene expression in target tissues. Thus, THRs alpha (TRa) and beta (TRb) function as TH dependent transcription ...

To read the full abstract: Front Endocrinol (Lausanne). 2018 Feb 28;9:54Secular trends in birth parameters1-3, growth4,5, and timing of puberty6-8 are observed in normal populations. Changes in nutrition, better access to health care, and other environmental factors have been implicated as causative factors for those changes. Here, the authors assessed secular ...

To read the full abstract: Cochrane Database Syst Rev. 2017; 11:CD008727Glucocorticoids (GCs), such as prednisone (prednisolone) or dexamethasone, are essential agents in the treatment of acute lymphoblastic leukemia (ALL), the most common malignancy in childhood. They are administered in highly supraphysiologic doses in cyclic courses. Thus, every pediatric endocrinologist fears HPA axi...

To read the full abstract: Dig Dis Sci. 2017;62:3110-3116This retrospective single-centre study is the first to report the impact of anti-tumor necrosis factor (anti-TNF) therapy on weight gain in children with inflammatory bowel disease (IBD). The results are consistent with data in adults, in whom weight gain during anti-TNF treatment was negatively correlated to pre-treatment BMI (1). A si...

To read the full abstract: Diabetologia. 2018;61:831-838T1DM in childhood and adolescence is a high burden for patients and family members. This is reflected by research that shows an increased incidence of psychiatric disorders in this patient group. Especially depression, eating disorders and anxiety disorders seem to be more prevalent. However data are mainly from small cohorts or regional...

To read the full abstract: Gastroenterology. 2017 Sep;153(3):711-722In adults, prebiotic intake is associated with improvements in satiety, postprandial glucose and insulin concentrations (1). The effect of prebiotic intervention in overweight/obese children has been rarely studied. This clinical trial showed that supplementation with oligofructose-enriched inulin for 16 weeks decreased BM...