ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Lancet Diabetes and Endocrinology 2018; 6: 114–121Cystic fibrosis (CF)-related diabetes (CFRD) impacts significantly on mortality and quality of life. Impaired glucose metabolism and CFRD are associated with poor weight and height gain and impaired lung function in children and adolescents (1). In that study, height and weight were lower in CF patients wit...

Pediatr Diabetes. 2018 May 15. doi: 10.1111/pedi.12691There is a small but significant debate as to whether or not type 1 (T1D) and type 2 diabetes (T2D) are the same disease with albeit different course. It might therefore be prudent to include into a chapter on T1D a publication on T2D. This study aimed to describe recent medication patterns and changes in medication patterns and glycemic con...

To read the full abstract: N Engl J Med. 2018;379(14):1303–1312.This analysis of longitudinal BMI data from early childhood to adolescents in 51,505 German subjects (CrescNet patient registry) allows a new insight into BMI development, specific dynamics and BMI trajectories from childhood to early adulthood.The exact pattern and time course of weight gain duri...

To read the full abstract: Cell Metabolism 2018; 28: 23–32Pathogenic mutations in the melanocortin-4 receptor gene (MC4R) are the most common cause of monogenic obesity. However, very limited treatment options exist. Therefore, these authors investigated a glucagon-like peptide-1 receptor agonist (GLP-1 RA) as a treatment option for these patients. The findings are of major signific...

To read the full abstract: Cell Reports. 2018 Dec 4;25(10):2643–2652.e4.More on the gut and the reward response: Ghrelin has been reported to encourage eating through dopamine that is important for the reward response. Here, the authors injected 38 subjects with ghrelin, while exposing them to various odors, both food and non-food based. They were also shown r...

To read the full abstract: Clin Endocrinol Metab. 2018 Feb 1;103(2):740-747Polycystic ovary syndrome (PCOS) is characterized by oligo-amenorrhoea, clinical and/or biochemical hyperandrogenism, polycystic ovaries, infertility and, commonly, insulin resistance, hyperinsulinaemia, morbid obesity and type 2 diabetes. The insulin-sensitizing drug metformin ameliorates the endocrinopathy of PCOS by red...

To read the full abstract: J Pediatr 2017; 187:206-12SRS is a clinically heterogeneous imprinting disorder. Although the understanding of its genetic basis has gradually advanced, about 40% of patients still have an unknown molecular defect. In subjects with unknown etiology, diagnosis is primarily clinical, based upon the Netchine-Harbison scoring system (NH-CSS) [31]. How...

To read the full abstract: Curr Opin Pediatr. 2017 Aug;29(4):475-480This is one of several editorials and position papers that has been published during the past year. It originates from the North American Pediatric Endocrine Society and its special interest group for transgender health. This article is of value for pediatricians dealing with any aspect of transgender health in children an...

To read the full abstract: PLoS One. 2018;13:e0193992Enterovirus infections in children are associated with an almost 10-fold higher risk of T1DM. In these families in parents and siblings enterovirus can frequently be detected by PCR. However, the role of enteroviral infections in the pathogenesis of T1DM is complex. Although enterovirus infections are less prevalent T1DM incidence increa...

To read the full abstract: JAMA. 2017;318:1358-1366Here, the authors compared the metabolic control in young patients with T1DM with insulin pump therapies versus multiple injection treatment modalities using the data from 30 579 patients younger than 20 years of age of 446 centers in a prospective population-based cohort study. While it is very clear that pump therapy, compared with injection ...