ESPEYB15 11 Obesity and Weight Regulation Smelling, tasting and weight gain (2 abstracts)
11.10 The Sense of Smell Impacts Metabolic Health and Obesity
Riera CE , Tsaousidou E , Halloran J , Follett P , Hahn O , Pereira MMA , Ruud LE , Alber J , Tharp K , Anderson CM , Brönneke H , Hampel B , Filho CDM , Stahl A , Brüning JC & Dillin A
Howard Hughes Medical Institute and Department of Molecular and Cell Biology, The Paul F. Glenn Center for Aging Research, University of California, Berkeley, USA
To read the full abstract: Cell Metab. 2017, Volume 26, Issue 1
Riera et al. developed ways to temporarily eliminate the sense of smell in adult mice. They discovered that mice lacking smell could eat a high-fat diet and stay significantly thinner than littermates with a normal sense of smell. Conversely, mice with hyperosmia gained more weight than wild-type mice on a high-fat diet. The fact that smell-deficient mice show an increase in energy expenditure suggests that the odor of what we eat may play an important role in how the body deals with calories. These new findings give us interesting insights in so far uninvestigated coherences but further research is needed to show the transferability of the findings in rodents to humans. Similarly, olfaction has well-established functions in rodent reproductive behaviour (acting via the vomeronasal organ), which are disputed in humans who lack the vomeronasal organ (1).
1. Trotier D. Vomeronasal organ and human pheromones. Eur Ann Otorhinolaryngol Head Neck Dis. 2011 Sep;128(4):184-90.
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