ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2021

3. Thyroid

Congenital hypothyroidism

ey0018.3-8 | Congenital hypothyroidism | ESPEYB18

3.8. Congenital hypothyroidism: A 2020-2021 consensus guidelines update-An ENDO-European Reference Network initiative endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology

P van Trotsenburg , A Stoupa , J Leger , T Rohrer , C Peters , L Fugazzola , A Cassio , C Heinrichs , V Beauloye , J Pohlenz , P Rodien , R Coutant , G Szinnai , P Murray , B Bartes , D Luton , M Salerno , L de Sanctis , M Vigone , H Krude , L Persani , M Polak

Thyroid. 2021:387–419. doi: 10.1089/thy.2020.0333.These updated ENDO-European Reference Network (ENDO-ERN), European Society for Paediatric Endocrinology (ESPE) and European Society for Endocrinology (ESE) guidelines for congenital hypothyroidism will serve as comprehensive review of the literature providing recommendations to all aspects of the disease.The first ...

ey0018.3-9 | Congenital hypothyroidism | ESPEYB18

3.9. Newborn screening TSH values less than 15 mIU/L are not associated with long-term hypothyroidism or cognitive impairment

R West , J Hong , JGB Derraik , D Webster , NL Heather , PL Hofman

J Clin Endocrinol Metab. 2020;105:dgaa415. doi: 10.1210/clinem/dgaa415.The optimal cut-off for neonatal screening has long been a matter of debate. The optimal balance between optimal detection of cases and increase of false positive patients is difficult to define. Also, in the most recent guidelines for congenital hypothyroidism (see previous paper in this chapter 3.7), no precise cut-off...

ey0018.3-10 | Congenital hypothyroidism | ESPEYB18

3.10. Cognitive and motor outcome in patients with early-detected central congenital hypothyroidism compared with siblings

JC Naafs , JP Marchal , E Fliers , PH Verkerk , MAJ Luijten , A Boelen , ASP van Trotsenburg , N Zwaveling-Soonawala

J Clin Endocrinol Metab. 2021;106:e1231–e1239. doi: 10.1210/clinem/dgaa901.The results of this study are a robust argument to implement neonatal screening for central congenital hypothyroidism (CCH) worldwide. Only few countries, such as the Netherlands, screen for CCH. Neurodevelopmental outcome data are scarce for CCH compared to primary congenital hypothyroidism (PCH) not only becau...