ISSN 1662-4009 (online)

Previous issue | Volume 18 | ESPEYB18 | Next issue

Yearbook of Paediatric Endocrinology 2021

7. Puberty

Basic Science

ey0018.7-8 | Basic Science | ESPEYB18

7.8. Oral contraceptive use, especially during puberty, alters resting state functional connectivity

R Sharma , Z Fang , A Smith , N Ismail

Horm Behav. 2020;126:104849. 10.1016/j.yhbeh.2020.104849. brief: This study used functional MRI to compare resting state functional connectivity in women who started oral contraception during puberty or ad...

ey0018.7-9 | Basic Science | ESPEYB18

7.9. ER[alpha] signaling in GHRH/Kiss1 dual-phenotype neurons plays sex-specific roles in growth and puberty

D Garcia-Galiano , AL Cara , Z Tata , SJ Allen , MG Jr Myers , E Schipani , CF Elias

J Neurosci. 2020 Dec 2;40(49):9455–9466. 10.1523/JNEUROSCI.2069-20.2020. PMID: 33158965 brief: These authors used two transgenic mouse models to assess the direct action of estrogens and androgens on GHRH neurons to control growth, pubertal development and reprod...

ey0018.7-10 | Basic Science | ESPEYB18

7.10. Central ceramide signaling mediates obesity-induced precocious Puberty

V Heras , JM Castellano , D Fernandois , I Velasco , E Rodriguez-Vazquez , J Roa , MJ Vazquez , F Ruiz-Pino , M Rubio , R Pineda , E Torres , MS Avendano , A Paredes , L Pinilla , D Belsham , C Dieguez , F Gaytan , N Casals , M Lopez , M Tena-Sempere

Cell Metab. 2020 Dec 1;32(6):951–966.e8. 10.1016/j.cmet.2020.10.001. PMID: 33080217. brief: This study reveals the critical role of hypothalamic ceramide synthesis in the induction of precocious puberty in obe...

ey0018.7-11 | Basic Science | ESPEYB18

7.11. MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons

AP Abreu , CA Toro , YB Song , VM Navarro , MA Bosch , A Eren , JN Liang , RS Carroll , AC Latronico , OK Ronnekleiv , CF Aylwin , A Lomniczi , S Ojeda , UB Kaiser

J Clin Invest. 2020 Aug 3;130(8):4486–4500. 10.1172/JCI136564. PMID: 32407292 brief: This study in rats and non-human primate models investigated the mechanisms by which MKRN3 regulates pubertal onset in rats and non-human primates.Comment: Pubertal timing is in...