ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2021

8. Adrenals

New Mechanisms

ey0018.8-2 | New Mechanisms | ESPEYB18

8.2. Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion

A Berthon , N Settas , A Delaney , A Giannakou , A Demidowich , FR Faucz , SB Seminara , ME Chen , CA Stratakis

Hum Mol Genet. 2020 Dec 18;29(20): 3443–3450. authors performed an experimental study in Kiss1 knock-out mice, followed by an observational study of patients with adrenal tumors. The findings indicate that KISS1/KISS1R signaling may be involved in obesity, metabolic disorders and even gonadal steroid hormone perturbations.<p class="abstex...