Nat Rev Endocrinol. 2021 Feb;17(2):114129. doi: 10.1038/s41574-020-00437-2. PMID: 33247226.
We highly recommend this comprehensive review by Prodam et al. to everyone as a starter to this chapter. How many of you knew that hypopituitarism in humans was first described just over 100 hundred years ago? The authors of this excellent review divide the causes of hypopituitarism to (i) pituitary and non-pituitary tumours, (ii) brain damage, (iii) infarction, (iv) autoimmune disorders, (v) genetic causes, (vi) infiltrative diseases, (vii) infections, (viii) drug-induced hypopituitarism, (ix) paraneoplastic syndromes (with anti-PIT1 and anti-POMC autoantibodies), and (x) other causes (such as snake bite!). The current understanding of the genetic causes underlying pituitary hormone deficiency is also summarized.