ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2022

11. Obesity and Weight Regulation

New findings in adipose tissue biology

ey0019.11-3 | New findings in adipose tissue biology | ESPEYB19

11.3. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

Z Jiang , M Zhao , L Voilquin , Y Jung , MA Aikio , T Sahai , FY Dou , AM Roche , I Carcamo-Orive , JW Knowles , M Wabitsch , EA Appel , CL Maikawa , JP Camporez , GI Shulman , L Tsai , ED Rosen , CD Gardner , BM Spiegelman , KJ Svensson Cell Metab 2021; 33(9): 1836–1852.e11 Summary: This rodent study identified a novel adipokine in mice which triggers a signaling cascade similar to that of insulin. By acting via an unknown tyrosine kinase, isthmin-1 (ISM1) ameliorates metabolic disturbances associated wit...

ey0019.11-4 | New findings in adipose tissue biology | ESPEYB19

11.4. Expression of the adipocyte progenitor markers MSCA1 and CD36 is associated with adipose tissue function in children

M Hanschkow , N Boulet , E Kempf , A Bouloumie , W Kiess , R Stein , A Korner , K Landgraf JCEM 2022; 107(2): e836–e851 Summary: This study investigated the association of the novel adipose-derived stem cell (ASC) markers Mesenchymal Stem cell Antigen 1 (MSCA1) and CD36 with adipose tissue function in samples collected from children...

ey0019.11-5 | New findings in adipose tissue biology | ESPEYB19

11.5. Insulin directly regulates the circadian clock in adipose tissue

N Tuvia , O Pivovarova-Ramich , V Murahovschi , S Luck , A Grudziecki , AC Ost , M Kruse , VJ Nikiforova , M Osterhoff , P Gottmann , O Gogebakan , C Sticht , N Gretz , M Schupp , A Schurmann , N Rudovich , AFH Pfeiffer , A Kramer Diabetes 2021;70:1985–1999 Summary: This study analyzed gene expression in subcutaneous adipose tissue samples of adults with obesity collected before and after the hyperinsulinemic–euglycemic clamp or control saline infusion. They demonstrate that insulin regulat...

ey0019.11-6 | New findings in adipose tissue biology | ESPEYB19

11.6. Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Q Li , CE Hagberg , HS Cascales , S Lang , MT Hyvonen , F Salehzadeh , P Chen , I Alexandersson , E Terezaki , MJ Harms , M Kutschke , N Arifen , N Kramer , M Aouadi , C Knibbe , J Boucher , A Thorell , KL Spalding Nat Med 2021; 27(11): 1941–1953 doi: 10.1038/s41591-021-01501-8Brief Summary: This study analysed adipocytes from obese and hyperinsulinemic adults. They demonstrate that obesity is associated with the induction of a cell cycle program in mature adipocytes, leading to so-called endoreplication, as a strategy to remain fu...

ey0019.11-7 | New findings in adipose tissue biology | ESPEYB19

11.7. Leptin resistance before and after obesity: evidence that tissue glucose uptake underlies adipocyte enlargement and liver steatosis/steatohepatitis in Zucker rats from early-life stages

MA Guzzardi , L Guiducci , D Campani , F La Rosa , A Cacciato Insilla , A Bartoli , M Cabiati , V De Sena , S Del Ry , S Burchielli , F Bonino , P Iozzo Int J Obes (Lond) 2022, 46(1):50–58. doi: 10.1038/s41366-021-00941-zBrief Summary: This experimental study was conducted with fa/fa rats that have a homozygous defect in the leptin receptor and therefore severe leptin resistance. The animals develop extreme obesity, diabetes and metabolic syndrome. The study of y...