ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2022

11. Obesity and Weight Regulation

Weight regulation and endocrine circuits (including interventions)

ey0019.11-11 | Weight regulation and endocrine circuits (including interventions) | ESPEYB19

11.11. The pubertal growth spurt is diminished in children with severe obesity

A Holmgren , GA Martos-Moreno , A Niklasson , J Martinez-Villanueva , J Argente , K Albertsson-Wikland Pediatr Res. 2021 Jul;90(1):184–190. doi: 10.1038/s41390-020-01234-3.Brief Summary: This observational study compared the pubertal growth spurt of children in a Spanish study group with severe early onset obesity to children in a Swedish community-based study. The authors show that childhood obesity i...

ey0019.11-12 | Weight regulation and endocrine circuits (including interventions) | ESPEYB19

11.12. Lower circulating sertoli and leydig cell hormone levels during puberty in obese boys: a cross-sectional study

S Rerat , J Amsellem-Jager , MC L'hour , N Bouhours-Nouet , A Donzeau , S Rouleau , L Levaillant , F Emeriau , V Moal , F Boux de Casson , N Lahlou , R Coutant J Clin Endocrinol Metab. 2022 Mar 24;107(4):e1568–e1576. doi: 10.1210/clinem/dgab845 Summary: This cross-sectional study describes how levels of Sertoli and Leydig cell hormones differ between 351 obese and overw...

ey0019.11-13 | Weight regulation and endocrine circuits (including interventions) | ESPEYB19

11.13. Weight gain and obesity rates in transgender and gender-diverse adults before and during hormone therapy

M Kyinn , K Banks , SY Leemaqz , E Sarkodie , D Goldstein , MS Irwig Int J Obes (Lond). 2021 Dec;45(12):2562–2569. doi: 10.1038/s41366-021-00935-x. Epub 2021 Aug 16. PMID: 34400797. Summary: This retrospective chart review of 470 ethnically diverse transgender and gender diverse in...

ey0019.11-14 | Weight regulation and endocrine circuits (including interventions) | ESPEYB19

11.14. Energy balance in hypothalamic obesity in response to treatment with a once-weekly GLP-1 receptor agonist

A Shoemaker , H Silver , M Buchowski , J Slaughter , J Yanovski , C Elfers , C Roth , MJ Abuzzahab International Journal of Obesity 2022, Epub 2022 Jan 3. doi: 10.1038/s41366-021-01043-6. Summary: This double-blind, placebo-controlled trial assessed the efficacy of 36 weeks of GLP1RA treatment with exenatide e...

ey0019.11-15 | Weight regulation and endocrine circuits (including interventions) | ESPEYB19

11.15. Impaired brain satiety responses after weight loss in children with obesity

CL Roth , SJ Melhorn , MRB De Leon , MG Rowland , CT Elfers , A Huang , BE Saelens , EA Schur J Clin Endocrinol Metab. 2022; doi: 10.1210/clinem/dgac299. Summary: In this intervention study, the effect of a 24-week family-based behavioral obesity intervention on brain activation, measured by v...

ey0019.11-16 | Weight regulation and endocrine circuits (including interventions) | ESPEYB19

11.16. Exenatide for weight-loss maintenance in adolescents with severe obesity: A randomized, placebo-controlled trial

CK Fox , JM Clark , KD Rudser , JR Ryder , AC Gross , BM Nathan , M Sunni , DR Dengel , CJ Billington , MO Bensignor , AS Kelly Obesity (Silver Spring) 2022, 30(5):1105–1115. Summary: This 52-week randomised placebo-controlled trial showed that exenatide XR improves stabilisation of BMI reduction after lifestyle intervention in adolescents with obesity.Maintaining weight loss after an in...

ey0019.11-17 | Weight regulation and endocrine circuits (including interventions) | ESPEYB19

11.17. Critical review of bariatric surgical outcomes in patients with Prader-Willi syndrome and other hyperphagic disorders

MG Gantz , DJ Driscoll , JL Miller , JB Duis , MG Butler , L Gourash , J Forster , AO Scheimann Obesity (Silver Spring) 2022, 30(5):973–981 Summary: This review analyzes the outcomes after bariatric procedures among patients with Prader-Willi syndrome (PWS), melanocortin 4 receptor (MC4R) mutations, Bardet-Biedl syndrome (BBS), and hypothalamic obesity (HO). The benef...