ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2022

3. Thyroid

Mechanism of the year

ey0019.3-1 | Mechanism of the year | ESPEYB19

3.1. Neonatal thyroxine activation modifies epigenetic programming of the liver

TL Fonseca , T Garcia , GW Fernandes , TM Nair , AC Bianco

Nat Commun. 2021 Jul 21;12(1):4446. doi: 10.1038/s41467-021-24748-8. PMID: 34290257Brief Summary: Jaundice is a major clinical sign of congenital hypothyroidism. LT4 treatment in hypothyroid neonates normalizes jaundice rapidly by inducing hepatocyte maturation. This mouse model study investigated the molecular mechanisms of thyroid hormone induced hepatocyte differentiation. A postnatal a...