ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2022

4. Growth and Growth Factors

Important for clinical practice

ey0019.4-1 | Important for clinical practice | ESPEYB19

4.1. Recombinant growth hormone therapy for X-linked hypophosphatemia in children

S Smith , T Remmington

Cochrane Database Syst Rev, 2021. 10: p. CD004447 PMID: 34618915Brief Summary: This systematic review examined the effects of rhGH treatment in children with X-linked hypophosphatemia. Despite a significant improvement in height SDS from baseline, evidence from the 2 identified studies was limited to support its clinical use in these patients.X-linked hypophosphatemia (XLH) is an inherited disorder of phosphate homeostasis...

ey0019.4-2 | Important for clinical practice | ESPEYB19

4.2. Recombinant growth hormone therapy for cystic fibrosis in children and young adults

V Thaker , B Carter , M Putman

Cochrane Database Syst Rev. 2021 Aug 23;8(8):CD008901.Division of Molecular Genetics and Department of Pediatrics, Columbia University Medical Center, New York, NY, USA. PMID: 34424546Brief Summary: This systematic review evaluated the efficacy and safety of rhGH therapy in improving lung function, quality of life and clinical status of children and young adults (aged up t...

ey0019.4-3 | Important for clinical practice | ESPEYB19

4.3. Growth hormone treatment in the pre-transplant period is associated with superior outcome after pediatric kidney transplantation

C Jagodzinski , S Mueller , R Kluck , K Froede , L Pavicic , J Gellermann , D Mueller , U Querfeld , D Haffner , M Zivicnjak

Pediatr Nephrol, 2022. 37(4): p. 859-869 PMID: 34542703Brief Summary: This prospective observational cohort study investigated growth rate after kidney transplant in children with chronic kidney disease (CKD) and growth failure, who received or did not receive rhGH treatment before transplantation. Patients pre-treated with rhGH showed better growth rates with taller height SDS at 7 years after transplantation. Positive effects of pre-transplant...

ey0019.4-4 | Important for clinical practice | ESPEYB19

4.4. Effects of growth hormone treatment on sleep-related parameters in adults with Prader-Willi syndrome

HH Shukur , L Hussain-Alkhateeb , Farholt S , O Norregaard , AP Jorgensen , C Hoybye

The Journal of Clinical Endocrinology & Metabolism, 2021, Vol. 106, No. 9, e3634–e3643PMID: 33950234Brief Summary: This trial explored the effects of rhGH treatment in patients with Prader-Willi syndrome (PWS) on respiratory and sleep parameters. The trial was randomized and placebo-controlled for 1 year, followed by a 2-year, open-phase GH treatment period. Polysomnography performed every 6 months revealed no adverse effects of rhGH tr...

ey0019.4-5 | Important for clinical practice | ESPEYB19

4.5. Oral nutritional supplementation improves growth in children at malnutrition risk and with picky eating behaviors

D Khanna , M Yalawar , PV Saibaba , S Bhatnagar , A Ghosh , P Jog , AV Khadilkar , B Kishore , AK Paruchuri , PD Pote , RD Mandyam , S Shinde , A Shah , DTT Huynh

Nutrients. 2021 Oct 14;13(10):3590. PMID: 34684591Brief Summary: This multi-center, prospective, randomized, double-blind study reports the effects of two different oral nutritional supplements (ONS) on growth in ‘picky eaters’ children at risk of malnutrition in India. Anthropometric measures (weight, height, weight-for-height, body mass index (BMI), and mid-upper-arm circumference were evaluated at day 1, 30, 60 and 90. Both types of...

ey0019.4-6 | Important for clinical practice | ESPEYB19

4.6. Serum testosterone and oestradiol predict the growth response during puberty promoting treatment

H Huttunen , T Varimo , H Huopio , R Voutilainen , S Tenhola , PJ Miettinen , T Raivio , M Hero

Clinical Endocrinology. 2022; 96:220–226. PMID: 34596269Brief Summary: This randomized controlled trial evaluated the effects of testosterone and aromatase inhibitor treatment on anthropometric measures, and their correlation with estradiol and testosterone serum levels in boys with constitutional delay of growth and puberty (CDGP), to elucidate the respective roles of the two sex steroid hormones on growth during puberty. The results sugge...