ESPE Yearbook of Paediatric Endocrinology

Nature. 2021 Jul;595(7867):455-459.Abstract: https://pubmed-ncbi-nlm-nih-gov/34194040/In brief: Using cryo-electron microscopy, the calcium-sensing receptor (CaSR) is visualized with different ligands demonstrating, in great detail, how calcimimetic drugs lock the CaSR homodimer in an assymetric configuration, exposing one of the two protomers for G-protein coupling, whereas calciolytic dru...

Science 2022 Apr 8;376(6589):188-192.Abstract: https://pubmed-ncbi-nlm-nih-gov/35389802/In Brief: The unique composition of organic and inorganic components allows bone to have remarkable biomechanical properties. This in vitro study reveals the phenomena of large contractile forces during intrafibrillar mineralization explaining the unusual mechanical properties of bone tissue.</p...

TOPMed Anthropometry Working Group; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium et al. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.Nat Genet. 2022 Mar;54(3):263-273.Abstract: https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/35256806/In brief: Genome-wide association studies (GWAS) on unrelated individuals rely...

J Bone Miner Res 36, 2300–2308. (2021)Abstract: https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/34346115/In brief: The genetic basis of human body height is only partly understood. This study combined genome-wide association study (GWAS) data with expression data from specific chondrocyte populations to identify genes responsible for skeletal growth. They found strong a...