ESPE Yearbook of Paediatric Endocrinology

Introduction: This year brought us some fascinating data regarding extra-hypothalamic GnRH neurons as well as a new player in puberty and growth regulation, MC3R. It also highlighted the crucial role of glial cells and tanycytes in the developmental processes leading to puberty. From a clinical point of view, this year’s studies opened new avenues for better discriminating between self-limiting delayed puberty and isolated hypogonadotropic hypogonadism....