ISSN 1662-4009 (online)

Previous issue | Volume 20 | ESPEYB20

Yearbook of Paediatric Endocrinology 2023

6. Adrenals

Food for Thought

ey0020.6-16 | Food for Thought | ESPEYB20

6.16. Brain structure in autoimmune Addison's disease

A Van't Westeinde , N Padilla , M Siqueiros Sanchez , S Fletcher-Sandersjoo , O Kampe , S Bensing , S Lajic

Brief summary: This study investigated the brain structure in young adult patients with autoimmune AddisonÂ’s disease (AAD). It found that patients with AAD had a 4.3% smaller total brain volume but no major differences in subcortical structures compared to healthy controls.Both short- and long-term disruptions in cortisol concentrations and rhythmicity affect brain structure development. Animal studies have shown that both pre- and postnatal disturb...