ISSN 1662-4009 (online)

Previous issue | Volume 20 | ESPEYB20

Yearbook of Paediatric Endocrinology 2023

6. Adrenals

New Mechanisms

ey0020.6-2 | New Mechanisms | ESPEYB20

6.2. Circadian regulation of hippocampal function is disrupted with corticosteroid treatment

MT Birnie , MDB Claydon , O Troy , BP Flynn , M Yoshimura , YM Kershaw , Z Zhao , RCR Demski-Allen , GRI Barker , EC Warburton , ZA Bortolotto , SL Lightman , BL Conway-Campbell

Brief summary: This study investigates the effect of long-acting synthetic glucocorticoids on circadian rhythmicity and hippocampal functionGlucocorticoids exert their effects by binding to glucocorticoid receptors (GRs), which regulate up to ~20% of the genome via both direct (by binding to glucocorticoid responsive elements in promoter regions) and indirect mechanisms (by interacting with bound transcription factors and epigenetic modifiers) (1...