ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica
Previous issue | Volume 20 | ESPEYB20

Yearbook of Paediatric Endocrinology 2023

7. Oncology and Chronic Disease

Gonadal Function and Fertility Issues in Childhood Cancer Survivors

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Carla Bizzarri, Sara Ciccone, Stefania Pedicelli
Table of contents
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Bone Health in Childhood Cancer Survivors

ey0020.7-1 | Gonadal Function and Fertility Issues in Childhood Cancer Survivors | ESPEYB20

7.1. Childhood cancer and hematological disorders negatively affect spermatogonial quantity at diagnosis: a retrospective study of a male fertility preservation cohort

I Masliukaite , E Ntemou , EAM Feijen , M van de Wetering , A Meissner , AT Soufan , S Repping , LMC Kremer , K Jahnukainen , E Goossens , AMM van Pelt

Brief summary: This multicentre retrospective cohort study evaluated testicular structure in 101 boys aged <14 years with solid tumors, CNS tumors, leukemia/lymphoma, or non-malignant hematological disorders, who were admitted for a fertility preservation programme between 2002 and 2018.The aim of the study was to clarify a possible role of the disease itself on the risk of infertility, independently of cancer therapies. Clinical data, testicular vol...
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ey0020.7-2 | Gonadal Function and Fertility Issues in Childhood Cancer Survivors | ESPEYB20

7.2. Towards an individualized management of pubertal induction in girls with hypogonadism: insight into the best replacement outcomes from a large multicentre registry

G Rodari , S Federici , T Todisco , G Ubertini , A Cattoni , M Pagano , F Giacchetti , E Profka , V Citterio , D Messetti , V Collini , D Soranna , E Carbone , M Arosio , G Mantovani , L Persani , M Cappa , M Bonomi , C Giavoli

Brief summary: This longitudinal observational multicentre retrospective study, collected data on 95 young prepubertal or early pubertal girls (age >10.9 years, Tanner stage ≤2) with premature ovarian failure (POI) or hypogonadotropic hypogonadism (HH). Their hypogonadism was due to different causes and was treated with transdermal 17β-oestradiol, with a follow-up of at least 1 year. The study aimed to identify the most physiological and effective therapeutic sc...
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ey0020.7-3 | Gonadal Function and Fertility Issues in Childhood Cancer Survivors | ESPEYB20

7.3. Hypothalamic-pituitary-gonadal function, pubertal development and fertility outcomes in male and female medulloblastoma survivors: a single centre experience

E Stern , M Ben-Ami , N Gruber , A Toren , S Caspi , G Abebe-Campino , M Lurye , M Yalon , D Modan-Moses

Brief summary: This single-centre retrospective study analysed gonadal function in 62 patients (41 males) with medulloblastoma, treated between 1987 and 2021. The aim of the study was to characterize gonadal function and identify risk factors for gonadal failure.Survival rates of patients with medulloblastoma have significantly improved with the combination of many therapeutic approaches, such as adjuvant chemotherapy, craniospinal irradiation (CSI), sur...
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ey0020.7-4 | Gonadal Function and Fertility Issues in Childhood Cancer Survivors | ESPEYB20

7.4. Reduced-intensity conditioning mitigates risk for primary ovarian insufficiency but does not decrease risk for infertility in pediatric and young adult survivors of hematopoietic stem cell transplantation

JD Bender , H Oquendo-Del Toro , J Benoit , JC Howell , P Badia , SM Davies , MS Grimley , S Jodele , C Phillips , K Burns , R Marsh , A Nelson , G Wallace , CE Dandoy , A Pate , AC Strine , O Frias , L Breech , SR Rose , H Hoefgen , P Khandelwal , KC Myers

Brief summary: This single-center, retrospective, cross-sectional study compared the prevalence of gonadal insufficiency and infertility among 58 pubertal, post pubertal and young adult survivors of hematopoietic stem cell Transplantation (HSCT), treated with conditioning regimens of different intensity.Gonadal insufficiency or infertility affects almost all HSCT survivors who received a myeloablative conditioning (MAC) regimen. In recent years, reduced-...
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ey0020.7-5 | Gonadal Function and Fertility Issues in Childhood Cancer Survivors | ESPEYB20

7.5. Ovarian function and spontaneous pregnancy after hematopoietic stem cell transplantation for leukemia before puberty: An L.E.A. cohort study

M Chabut , P Schneider , B Courbiere , P Saultier , Y Bertrand , MD Tabone , C Pochon , S Ducassou , C Paillard , V Gandemer , J Kanold , JH Dalle , M Poiree , G Plat , S Thouvenin , D Plantaz , N Sirvent , S Weinhard , J Berbis , A Baruchel , G Leverger , Z Hamidou , P Auquier , G Michel

Brief summary: This French retrospective observational study evaluated ovarian function, premature ovarian insufficiency (POI) and spontaneous pregnancy in 178 women who had undergone hematopoietic stem cell transplantation (HSCT) for leukemia before puberty; 116/178 had received total body irradiation (TBI) and 62 had received a busulfan-based conditioning regimen.Sixty percent of women needed pubertal induction; only 40% had spontaneous menarche and ha...
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ey0020.7-6 | Gonadal Function and Fertility Issues in Childhood Cancer Survivors | ESPEYB20

7.6. The impact of vincristine on testicular development and function in childhood cancer

I Clark , MFH Brougham , N Spears , RT Mitchell

Brief summary: This is a systematic review on the effects of vincristine-containing regimens, commonly considered to have low gonadotoxicity, on human prepubertal testis, after the reports of testicular tissue abnormalities and severely impaired fertility due to vincristine exposure in prepubertal rodents.Twenty-four studies were identified that reported testicular development and fertility after treatment with vincristine-containing regimens. Only 9/24 ...
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ey0020.7-7 | Gonadal Function and Fertility Issues in Childhood Cancer Survivors | ESPEYB20

7.7. The uterine volume is dramatically decreased after hematopoietic stem cell transplantation during childhood regardless of the conditioning regimen

B Courbiere , B Drikes , A Grob , Z Hamidou , P Saultier , Y Bertrand , V Gandemer , D Plantaz , G Plat , M Poiree , S Ducassou , C Pochon , JH Dalle , S Thouvenin , C Paillard , J Kanold , A Sirvent , C Rousset-Jablonski , S Duros , A Gueniffey , C Cohade , S Boukaidi , S Frantz , M Agopiantz , C Poirot , A Genod , O Pirrello , AS Gremeau , S Bringer-Deutsch , P Auquier , G Michel

Brief summary: This French multicenter prospective study analyzed uterine volume by pelvic MRI in 88 women (age range 18–40 years), who were survivors of childhood acute leukemia treated with hematopoietic stem cell transplantation (HSCT). They were compared to 88 healthy women matched for age and parity.Conditioning regimens before HSCT included alkylating agents for 34 women and total body irradiation (TBI) for 54 women. Scans were centralized and...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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