ESPE Yearbook of Paediatric Endocrinology

Another year has passed, and with it, exciting scientific developments in pediatric endocrinology and diabetology. We had an early glimpse of the latest literature at three oral sessions during the inaugural combined ESPE/ICE meeting in Copenhagen, Denmark—an event that proved to be a resounding success.

Now, we are pleased to present the Yearbook 2025, comprising 15 topic-based chapters, each curated by experts in their respective fields. The number of publications continues to grow rapidly. In basic science, single-cell sequencing and ex vivo/in vitro methods took center stage, while novel bioinformatic tools allowed for deeper insights into the genetic landscape of health and disease. Translational studies increasingly blend fundamental and clinical approaches to explore disease mechanisms. Unsurprisingly, machine learning has made a strong entrance into our field, offering both exciting opportunities—and perhaps a few challenges. Most notably, we are witnessing the arrival of a whole new spectrum of medications in the pediatric space, with promising potential to transform outcomes for children and adolescents affected by both rare and common endocrine conditions.

We are deeply grateful to the Chapter Editors, whose dedication to reviewing this year's literature and providing critical commentary has once again made this yearbook possible. Their insights on the impact, limitations, and knowledge gaps in recent research are invaluable. Like last year, members of The Young ESPE (YES) group have also contributed to each chapter, and we thank these highly motivated early-career professionals for their involvement. Their fresh perspectives are a clear testament to the bright future ahead for our field.

We hope you enjoy reading the Yearbook 2025 and find inspiration and knowledge within its pages.

Warmest regards,

Christa E. Flück and Ken K. Ong