Puberty

Julie Fudvoye; Caroline Gernay; Dimitrije Cvetković; Anne-Simone Parent

doi:10.1530/ey.22.7.0

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ESPE Yearbook of Paediatric Endocrinology (2025) 22 7.0 | DOI: 10.1530/ey.22.7.0

ESPEYB25 7. Puberty Julie Fudvoye, Caroline Gernay, Dimitrije Cvetković, Anne-Simone Parent (1 abstracts)

7. Puberty

Julie Fudvoye ^1,2 , Caroline Gernay ¹ , Dimitrije Cvetković ³ & Anne-Simone Parent ^1,2

Author affiliations

¹Department of Pediatrics, University Hospital Liège, Belgium; ²Neuroendocrinology Unit, GIGA-Neurosciences, University of Liège, Belgium; ³Department of Pediatric Endocrinology, Mother and Child Health Care Institute of Serbia "Dr VukanCupic", Belgrade, Serbia (YES member)

Introduction: This year’s publications highlight puberty’s intricate regulation by genetic, metabolic, and environmental factors. Urinary estrone emerges as a potential biomarker of metabolic risk in adolescent girls, while DLK1 dynamics and urinary LH offer insights into pubertal staging. The COVID-19 pandemic revealed a surge in central precocious puberty (CPP), prompting investigation into psychosocial and behavioral triggers. Genetic studies identified novel candidates for delayed puberty. Neuroendocrine research uncovered how hypothalamic lipid-sensing and AgRP–Kisspeptin circuits mediate nutritional influences on pubertal timing. Finally, Mendelian randomization linked early puberty to adverse adult metabolic profiles, and rare variants in DNA repair genes connected reproductive ageing to cancer risk and intergenerational effects. Together, these findings redefine puberty as a critical window for lifelong health programming.