ISSN 1662-4009 (online)

ey0018.2-6 | Neonatal hypoglycaemia | ESPEYB18

2.6. Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes.

S Tornovsky-Babeay , N Weinberg-Corem , R Ben-Haroush Schyr , D Avrahami , J Lavi , E Feleke , KH Kaestner , Y Dor , B Glaser

Diabetologia. 2021 May;64(5):1133-1143. doi: 10.1007/s00125-021-05390-x. PMID: 33558985.In order to gain some insight into the potential mechanism/s of diminished beta cell function over time, this mouse model of CHI was developed with an activating GCK (Glucokinase) mutation. In the short term, the mice developed mild fasting hypoglycaemia (this was very mild with fasting blood glucose...