ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2021

ey0018.2-1 | Neonatal hypoglycaemia | ESPEYB18

2.1. Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants

Cochrane Database Syst Rev. 2020 Dec 21;12:CD013309. doi: 10.1002/14651858.CD013309.pub2. PMID: 33348448.This Cochrane review aimed to assess the use of continuous glucose monitoring (CGM) in preterm infants. It finds limited evidence to support the use of CGM devices to improve mortality or morbidity in preterm infants.Both hypoglycaemia and hyperglycaemia ar...

ey0018.2-2 | Neonatal hypoglycaemia | ESPEYB18

2.2. Accuracy of continuous glucose monitoring in preterm infants: a systematic review and meta-analysis.

C Nava , A Modiano Hedenmalm , F Borys , L Hooft , M Bruschettini , K Jenniskens

BMJ Open. 2020 Dec 24;10(12):e045335. doi: 10.1136/bmjopen-2020-045335. PMID: 33361084This BMJ review aimed to assess the accuracy of CGM devices to detect hypoglycaemia and hyperglycaemia in preterm infants. The key take home messages from the BMJ review were that the sensitivity for CGM devices to diagnose and detect hypoglycaemia in preterm infants was poor but the specificity was h...

ey0018.2-3 | Neonatal hypoglycaemia | ESPEYB18

2.3. Neonatal hyperglycaemia is associated with worse neurodevelopmental outcomes in extremely preterm infants.

I Zamir , Sjostrom E Stoltz , F Ahlsson , I Hansen-Pupp , F Serenius , M Domellof

Arch Dis Child Fetal Neonatal Ed. 2021 Apr 16. Epub ahead of print. doi: 10.1136/archdischild-2020-319926. PMID: 33863775.This observational study highlights the potential detrimental long-term effects of neonatal hyperglycaemia on neurodevelopmental outcomes in extremely preterm infants, while the benefit of insulin treatment remains unclear.Hyperglycaemia ...

ey0018.2-4 | Neonatal hypoglycaemia | ESPEYB18

2.4. Glucose Profiles in Healthy Term Infants in the First 5 Days: The Glucose in Well Babies (GLOW) Study.

DL Harris , PJ Weston , GD Gamble , JE Harding

J Pediatr. 2020 Aug;223:34–41.e4. doi: 10.1016/j.jpeds.2020.02.079. PMID: 32381469.In this study, the plasma and interstitial (GCMS) glucose levels were measured in term healthy newborns for a period of 5 days to understand the changes in the glucose levels after birth. The findings suggest that in normal term healthy newborns if hypoglycaemia persists after the 4th day of life, t...

ey0018.2-5 | Neonatal hypoglycaemia | ESPEYB18

2.5. SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism.

V Lithovius , J Saarimaki-Vire , D Balboa , H Ibrahim , H Montaser , T Barsby , T Otonkoski

Diabetologia. 2021 Mar;64(3):630-640. doi: 10.1007/s00125-020-05346-7. PMID: 33404684.The derivation of iPSCs and their subsequent conversion to islet like clusters from a patient with diffuse CHI due to a homozygous mutation in the ABCC8 provided these authors a unique opportunity to study the molecular basis of CHI and to develop potential novel treatment options by screening...

ey0018.2-6 | Neonatal hypoglycaemia | ESPEYB18

2.6. Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes.

S Tornovsky-Babeay , N Weinberg-Corem , R Ben-Haroush Schyr , D Avrahami , J Lavi , E Feleke , KH Kaestner , Y Dor , B Glaser

Diabetologia. 2021 May;64(5):1133-1143. doi: 10.1007/s00125-021-05390-x. PMID: 33558985.In order to gain some insight into the potential mechanism/s of diminished beta cell function over time, this mouse model of CHI was developed with an activating GCK (Glucokinase) mutation. In the short term, the mice developed mild fasting hypoglycaemia (this was very mild with fasting blood glucose...

ey0018.2-7 | Neonatal hypoglycaemia | ESPEYB18

2.7. Possible new strategies for the treatment of congenital hyperinsulinism

J Sikimic , T Hoffmeister , A Gresch , J Kaiser , W Barthlen , C Wolke , I Wieland , U Lendeckel , P Krippeit-Drews , M Dufer , G Drews

Front Endocrinol (Lausanne). 2020 Oct 27;11:545638. doi: 10.3389/fendo.2020.545638. PMID: 33193079.Using human islets from CHI patients and islets from ABCC8 (SUR1) knockout mice, the authors tested several novel compounds to inhibit insulin over-secretion. These novel compounds targeted KATP channels as well as KATP indepe...