ISSN 1662-4009 (online)

ey0018.11-7 | New insight: neurobiology and weight regulation | ESPEYB18

11.7. Genetic mapping of etiologic brain cell types for obesity

PN Timshel , JJ Thompson , TH Pers

eLife 2020;9:e55851. et al. describe a novel strategy for integrating single-cell RNA-sequencing (scRNA-seq) data with GWAS data on BMI associated genetic variants, and thereby identify 26 exclusively neuronal cell types that are significantly enriched for BMI heritability.The authors developed two scRNA-seq computation...