ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2021

11. Obesity and Weight Regulation

New insight: neurobiology and weight regulation

ey0018.11-6 | New insight: neurobiology and weight regulation | ESPEYB18

11.6. Child neurobiology impacts success in family-based behavioral treatment for children with obesity

EA Schur , SJ Melhorn , K Scholz , MRB De Leon , CT Elfers , MG Rowland , BE Saelens , CL Roth

Int J Obes (Lond). 2020 Oct;44(10):2011–2022. 10.1038/s41366-020-0644-1. et al. addressed the question, whether responsiveness to visual food cues in functional magnetic resonance imaging (fMRI) is related to the treatment success of a 6-month Family-based Behavioral Treatment (...

ey0018.11-7 | New insight: neurobiology and weight regulation | ESPEYB18

11.7. Genetic mapping of etiologic brain cell types for obesity

PN Timshel , JJ Thompson , TH Pers

eLife 2020;9:e55851. et al. describe a novel strategy for integrating single-cell RNA-sequencing (scRNA-seq) data with GWAS data on BMI associated genetic variants, and thereby identify 26 exclusively neuronal cell types that are significantly enriched for BMI heritability.The authors developed two scRNA-seq computation...