ISSN 1662-4009 (online)

ey0016.8-1 | Mechanism of the Year: Endogenous glucocorticoids suppress immunopathology and promote host resistance to viral infection without compromising protective immunity | ESPEYB16

8.1. Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells

L Quatrini , E Wieduwild , B Escaliere , J Filtjens , L Chasson , C Laprie , E Vivier , S Ugolini

To read the full abstract: Nat Immunol. 2018; 19(9): 954–962.The immune system protects the host organism against infectious diseases, however, pathogen elimination frequently entails collateral tissue damage and inflammation, which decrease host fitness (1). Neuroendocrine-immune interactions play an important role in these regulatory processes (2, 3). Endogenous glucocorticoids (c...