ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Pediatr 2018;193:134-138.e1Obesity promotes visceral fat deposition, which may result in profound metabolic consequences that contribute directly to insulin resistance, and risk of cardiovascular disease and malignancy. Obese individuals are at increased risk of fatty liver disease, which can lead to steatohepatitis and subsequently advanced liver fibrosis. Less...

Hypertriglyceridemia (HTG) is known to be a risk factor for cardiovascular diseases, such as atherosclerosis and hypertension. Although the association between insulin resistance (IR) and HTG has long been recognized, the causal relationship between them has not been elucidated yet. Proper understanding of the effect of IR on HTG may better start with the realization that IR implies much more than mere impairment of glucose uptake in tissues. Given that the role of insulin is ...

qhfka9357@naver.com Integr Med Res 11 (2022) 100832. doi: 10.1016/j.imr.2022.100832Brief Summary: This systematic review found that East Asian traditional medicine (EATM) therapies may have beneficial effects in children with idiopathic short stature, however, high-quality studies are necessary.The authors reviewed 14 studies (...

Nat Commun. 2021 Jan 11;12(1):256. doi: 10.1038/s41467-020-20511-7. PMID: 33431871.These authors report two Mll4 mutant mouse models that exhibited dwarfism and altered development of GHRH−neurons.Inactivating mutations in KDM6A (aka UTX) or KMT2D (aka MLL4) genes result in Kabuki syndrome (KS), whose hallmarks in...

To read the full abstract: J Clin Endocrinol Metab 2018;103:158-168Defects at the GNAS locus give rise to various phenotypes, several of which are associated with subcutaneous ossifications (SCOs), which cause significant morbidity among the affected individuals. A subgroup of patients with paternally inherited GNAS mutations have progressive osseous heteroplasia (POH), characterized by severe he...

To read the full abstract: Nat Commun. 2019 Aug 16;10(1):3696. doi: 10.1038/s41467-019-11667-y. PMID: 31420539.The hypothalamic arcuate nucleus (ARC) controls crucial physiological processes, such as growth, reproduction and energy homeostasis. However, it is unknown how ARC neurons gain their unique cellular identities and what are their developmental relationships. Here, the authors i...

Nature 2020 Dec; 588(7836): 112–117https://go.nature.com/3go7UjOThirst is sensed by two distinct types of stimuli – osmotic and hypovolaemic. The authors show that in mice these two stimuli act via separate mechanisms and neuron types, and lead to distinct drinking behavioural responses. High blood osmolality induces osmotic thirst that drives water consumption. By contrast, hypovolaemia driv...

J Clin Oncol. 2022 May 1;40(13):1439-1449. doi: 10.1200/JCO.21.01841. Epub 2022 Jan 19. PMID: 35044839Brief Summary: This retrospective study showed that children and young adults (< 45 years) treated with radioactive iodine (RAI) for primary Differentiated Thyroid Cancer (DTC) have increased risks for leukemia and solid cancers, particularly beyond 20 years after treatment.<p class="abs...

Brief Summary: This prospective, pragmatic, open-label study assessed the impact of a systematic and equitable digital-health-team-based care program designed to achieve tight glycemic targets (HbA1c <7%) through early technology use and remote patient monitoring, in young people with newly diagnosed T1D. The program was successful: 68% of participants achieved target HbA1c, and an average 65% time in glucose range at one-year post-diagnosis.Despite ...

Brief Summary: This experimental study quantified the physiological contribution of pancreatic δ-cells to the glycemic set point. It used 3 orthogonal mouse models to remove somatostatin (SST) signalling within the pancreas or transplanted islets. Ablation of δ-cells or SST decreased the glycemic set point, and the glucose threshold for insulin response from β-cells, leading to increased insulin secretion to the same glucose challenge.The ...